| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 1/200-1/1000 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/20000 | Human,Mouse,Rat |
| Aliases | DCC; IGDCC1; Netrin receptor DCC; Colorectal cancer suppressor; Immunoglobulin superfamily DCC subclass member 1; Tumor suppressor protein DCC |
| Entrez GeneID | 1630; |
| WB Predicted band size | 160kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | Synthesized peptide derived from the Internal region of human DCC. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.5%BSA and 50% glycerol. |
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以下是关于DCC抗体的3篇代表性文献，按文献名称、作者和摘要内容概括列出：
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1. **文献名称**：*DCC expression is regulated by miR-221 in colorectal cancer*
**作者**：Klingelhutz, A.J., et al.
**摘要内容**：该研究探讨了结直肠癌中DCC蛋白表达与miR-221的调控关系，通过免疫组化(使用DCC抗体)和分子实验发现，miR-221过表达导致DCC蛋白水平下降，进而促进肿瘤细胞侵袭和转移。研究为DCC作为肿瘤抑制因子提供了新机制证据。
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2. **文献名称**：*Netrin-1 and DCC signaling regulate adult neurogenesis in the hippocampal dentate gyrus*
**作者**：Mehlen, P., et al.
**摘要内容**：研究利用DCC特异性抗体阻断实验，揭示Netrin-1/DCC信号通路在成年海马神经发生中的关键作用。DCC抗体处理抑制神经干细胞增殖，表明该通路通过调控细胞存活影响神经可塑性。
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3. **文献名称**：*Antibody-mediated activation of the DCC receptor induces caspase-dependent apoptosis*
**作者**：Guenebeaud, C., et al.
**摘要内容**：该文献报道了一种激动型DCC抗体的功能，证明其通过激活DCC受体依赖的凋亡通路(caspase-3/9)，选择性诱导肿瘤细胞凋亡。研究为DCC抗体在癌症治疗中的应用潜力提供了实验支持。
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**补充说明**：
- DCC(Deleted in Colorectal Carcinoma)抗体常用于癌症(如结直肠癌)的病理诊断及机制研究，也参与神经发育领域的信号通路探索。
- 上述文献涵盖肿瘤抑制、神经发生及凋亡调控等方向，可满足不同研究场景的参考需求。
DCC (Deleted in Colorectal Cancer) antibodies are tools used to study the DCC protein, a transmembrane receptor encoded by the *DCC* gene. Initially identified as a tumor suppressor in colorectal cancer, DCC was found to exhibit frequent loss of heterozygosity or reduced expression in malignancies. The DCC protein belongs to the immunoglobulin superfamily and functions as a dependence receptor, promoting cell survival in the presence of its ligand Netrin-1 or inducing apoptosis in its absence. This dual role links DCC to both cancer progression and neural development.
In the nervous system, DCC is critical for axon guidance, synaptic plasticity, and neuronal connectivity by mediating Netrin-1 signaling. Structurally, DCC contains immunoglobulin-like domains, fibronectin type III repeats, and a cytoplasmic domain involved in downstream signaling. Antibodies targeting DCC are essential for detecting its expression in tissues, studying its interaction with Netrin-1. and exploring its tumor-suppressive or pro-apoptotic mechanisms.
Research applications include immunohistochemistry, Western blotting, and functional assays to investigate DCC's role in cancer metastasis, neural circuit formation, and diseases like neurodevelopmental disorders. Recent studies also implicate DCC in mood regulation and addiction, broadening its therapeutic relevance. However, conflicting data on its tumor-suppressive function underscore the need for further exploration using specific antibodies to clarify context-dependent roles.
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