| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/300 | Human,Mouse,Rat |
| ICC | 1/200-1/1000 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/10000 | Human,Mouse,Rat |
| Aliases | CDH16; Cadherin-16; Kidney-specific cadherin; Ksp-cadherin |
| Entrez GeneID | 1014; |
| WB Predicted band size | 90kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthesized peptide derived from the C-terminal region of human Cadherin-16. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.5%BSA and 50% glycerol. |
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以下是3条关于Cadherin-16(KSP-cadherin)抗体的参考文献，内容基于真实研究整理，但文献标题和作者为模拟示例：
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1. **文献名称**: *Characterization of a novel monoclonal antibody against human Cadherin-16 and its application in renal tissue analysis*
**作者**: Tanaka, R., et al.
**摘要**: 研究团队开发了一种特异性识别Cadherin-16的小鼠单克隆抗体(克隆号：KSP-3B2)，通过免疫组化验证其在肾组织中的表达，证实其适用于检测远端肾小管上皮细胞，并用于鉴别肾细胞癌亚型。
2. **文献名称**: *Cadherin-16 as a biomarker in chronic kidney disease: Validation of a polyclonal antibody-based ELISA assay*
**作者**: Zhang, L., & Wang, H.
**摘要**: 通过制备兔多克隆抗体，建立了一种定量检测血清中Cadherin-16的ELISA方法，发现其在慢性肾病患者的血清水平显著升高，提示其作为肾功能损伤标志物的潜力。
3. **文献名称**: *Comparative study of Cadherin-16 antibody specificity across species using immunohistochemistry and Western blot*
**作者**: Müller, S., et al.
**摘要**: 对比了多种市售Cadherin-16抗体在人、小鼠和大鼠组织中的交叉反应性，发现部分抗体存在非特异性结合，强调了抗体验证在跨物种研究中的重要性，并推荐了两种高特异性抗体(货号：AbX-203和AbY-115)。
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**备注**：实际研究中可参考以下方向检索文献：
- 检索关键词：**Cadherin-16 antibody/KSP-cadherin antibody** + **application/validation**
- 推荐数据库：PubMed、Google Scholar、抗体公司官网(如Abcam、Thermo Fisher的技术文档)
Cadherin-16 (CDH16), also known as kidney-specific cadherin (KSP-cadherin), is a calcium-dependent cell adhesion molecule predominantly expressed in the kidney, specifically in renal tubular epithelial cells. As a member of the cadherin superfamily, it plays a critical role in maintaining tissue architecture, cell polarity, and intercellular adhesion. CDH16 is involved in nephrogenesis and renal tissue homeostasis, with its expression tightly regulated during kidney development and repair. Dysregulation of CDH16 has been implicated in renal pathologies, including renal cell carcinoma (RCC), polycystic kidney disease, and fibrosis.
Antibodies targeting CDH16 are valuable tools for studying its localization, expression patterns, and functional roles in both normal and diseased tissues. These antibodies are widely used in immunohistochemistry (IHC), immunofluorescence (IF), and Western blotting to identify CDH16 in kidney-specific research. In diagnostic contexts, CDH16 antibodies aid in distinguishing renal tumors from other malignancies due to its tissue-restricted expression. For instance, CDH16 immunostaining helps differentiate chromophobe RCC from oncocytoma or clear cell RCC. However, antibody specificity must be validated to avoid cross-reactivity with other cadherins. Recent studies also explore CDH16's potential as a biomarker for renal injury or regeneration. Ongoing research continues to unravel its mechanistic contributions to kidney diseases, emphasizing the importance of reliable CDH16-targeting reagents.
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