| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/40000 | Human,Mouse,Rat |
| Aliases | CA12; Carbonic anhydrase 12; Carbonate dehydratase XII; Carbonic anhydrase XII; CA-XII; Tumor antigen HOM-RCC-3.1.3 |
| Entrez GeneID | 771; |
| WB Predicted band size | 39kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | Synthesized peptide derived from the Internal region of human CA XII. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.5%BSA and 50% glycerol. |
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以下是3篇关于CA XII抗体的参考文献示例(注：以下文献信息为示例性质，实际引用请核对真实来源)：
1. **文献名称**: *Carbonic anhydrase XII expression is associated with poor prognosis in renal cell carcinoma*
**作者**: Ivanova S, et al.
**摘要**: 研究通过免疫组化分析肾癌组织中CA XII的表达，发现其高表达与患者生存期缩短相关，提示CA XII可能作为预后生物标志物，并参与肿瘤微环境酸化调控。
2. **文献名称**: *Monoclonal antibody targeting CA XII enhances the efficacy of chemotherapy in hypoxic tumors*
**作者**: McDonald PC, Dedhar S.
**摘要**: 开发针对CA XII的单克隆抗体，证实其可抑制肿瘤细胞外pH调节，增强化疗药物在低氧肿瘤模型中的疗效，突显其作为联合治疗靶点的潜力。
3. **文献名称**: *Differential expression of carbonic anhydrase isoforms in glioblastoma: CA XII as a therapeutic target*
**作者**: Haapasalo J, et al.
**摘要**: 比较胶质母细胞瘤中不同CA亚型表达，发现CA XII在侵袭边缘显著上调，抗体阻断实验显示其抑制肿瘤细胞迁移，支持其在靶向治疗中的应用价值。
如需进一步文献，建议在PubMed或Web of Science中检索关键词“CA XII antibody”、“carbonic anhydrase XII cancer”。
Carbonic anhydrase XII (CA XII) is a zinc-containing enzyme belonging to the carbonic anhydrase family, which regulates pH homeostasis by catalyzing the reversible hydration of carbon dioxide to bicarbonate and protons. It is a transmembrane protein predominantly expressed in normal tissues such as the intestines, kidneys, and brain, but is also overexpressed in various cancers, including renal cell carcinoma, gliomas, and breast cancer. CA XII plays a key role in tumor progression by acidifying the extracellular microenvironment, promoting invasion, metastasis, and resistance to therapies.
CA XII antibodies are immunological tools designed to detect and study the expression, localization, and function of this enzyme. These antibodies are widely used in research to investigate CA XII's association with hypoxia-inducible factor 1 (HIF-1)-driven pathways in tumors, as CA XII expression is often upregulated under hypoxic conditions. They are also employed in diagnostic applications, such as immunohistochemistry, to identify CA XII as a potential biomarker for certain cancers or to assess therapeutic targeting efficacy.
Recent studies explore CA XII inhibitors (e.g., small molecules or monoclonal antibodies) for anticancer therapies, aiming to disrupt pH regulation in tumors. Additionally, CA XII antibodies contribute to understanding its role in non-cancer pathologies, like retinal diseases and fibrosis. Ongoing research focuses on optimizing antibody specificity and developing clinical-grade reagents for diagnostic and therapeutic use.
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