| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/300 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/40000 | Human,Mouse,Rat |
| Aliases | BMP7; OP1; Bone morphogenetic protein 7; BMP-7; Osteogenic protein 1; OP-1; Eptotermin alfa |
| Entrez GeneID | 655; |
| WB Predicted band size | 55kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | Synthesized peptide derived from the Internal region of human BMP-7. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.5%BSA and 50% glycerol. |
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以下是关于BMP-7抗体的简要参考文献信息(内容为模拟概括，仅供参考)：
1. **文献名称**：*"BMP-7 Antibody Attenuates Renal Fibrosis in a Mouse Model"*
**作者**：Vukicevic, S. et al.
**摘要**：研究通过BMP-7抗体抑制实验，证明BMP-7在肾脏纤维化中的关键作用，并探讨其通过调节TGF-β信号通路减轻纤维化的机制。
2. **文献名称**：*"A Monoclonal Antibody to BMP-7 Inhibits Tumor Angiogenesis in Vivo"*
**作者**：Hao, J. et al.
**摘要**：开发一种特异性BMP-7单克隆抗体，发现其可通过阻断BMP-7与内皮细胞受体的结合，显著抑制肿瘤微环境中的血管生成。
3. **文献名称**：*"BMP-7 Neutralizing Antibody Reduces Bone Formation in Osteoporosis Models"*
**作者**：Rosen, V. & Harris, S.E.
**摘要**：利用中和抗体研究BMP-7在骨代谢中的功能，发现阻断BMP-7会抑制成骨细胞分化，提示其作为骨质疏松治疗的潜在靶点。
4. **文献名称**：*"Development of a High-Specificity BMP-7 Antibody for Immunohistochemistry"*
**作者**：Hruska, K.A. et al.
**摘要**：报道一种新型BMP-7抗体的开发与验证，该抗体在组织样本中具有高灵敏度和特异性，可用于慢性肾病中BMP-7表达的精准检测。
(注：上述内容为示例性概括，实际文献需通过学术数据库查询确认。)
BMP-7 (bone morphogenetic protein-7), also known as osteogenic protein-1 (OP-1), is a multifunctional cytokine belonging to the TGF-β superfamily. It plays critical roles in embryonic development, tissue repair, and homeostasis, particularly in bone formation, renal development, and cartilage maintenance. In adults, BMP-7 is expressed in various tissues, including kidneys, bones, and the nervous system, where it regulates cell differentiation, apoptosis, and extracellular matrix synthesis. Dysregulation of BMP-7 signaling is implicated in chronic kidney disease, osteoarthritis, and cancer progression.
BMP-7 antibodies are essential tools for detecting and quantifying BMP-7 in research and diagnostics. They enable applications such as Western blotting (WB), immunohistochemistry (IHC), and ELISA to study BMP-7 expression patterns, signaling pathways, and therapeutic potential. Polyclonal antibodies recognize multiple epitopes, offering broad detection sensitivity, while monoclonal antibodies provide high specificity for targeted epitopes. Validated BMP-7 antibodies help investigate its role in disease mechanisms, such as fibrosis inhibition or osteoblast activation, and support drug development efforts targeting BMP-7-related pathways. Selecting appropriate antibodies requires considering factors like species reactivity, cross-reactivity, and compatibility with specific experimental workflows.
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