Rabbit Polyclonal ABCC13 Antibody

The ABCC13 gene encodes a member of the ATP-binding cassette (ABC) transporter superfamily, which facilitates the transport of various substrates across cellular membranes. Although ABCC13 is considered a pseudogene in most humans due to premature stop codons, functional forms exist in other species. Research suggests it may play roles in drug metabolism, detoxification, and lipid transport. ABCC13 antibodies are immunological tools developed to detect and study the protein's expression, localization, and potential functions. These antibodies are primarily used in research settings for techniques like Western blotting, immunohistochemistry, and immunofluorescence. Interest in ABCC13 stems from its evolutionary relationship to other ABC transporters linked to multidrug resistance in cancers, though its direct clinical relevance remains unclear. Studies have explored its expression patterns in tissues like the liver, testes, and gastrointestinal tract. However, its pseudogene status in humans complicates functional characterization, and findings often rely on comparative analyses with functional orthologs in model organisms. Current research focuses on clarifying its biological significance and potential involvement in disease mechanisms or cellular responses to xenobiotics.