| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/40000 | Human,Mouse,Rat |
| Aliases | ABCA8; KIAA0822; ATP-binding cassette sub-family A member 8 |
| Entrez GeneID | 10351; |
| WB Predicted band size | 179kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse |
| Immunogen | Synthesized peptide derived from the Internal region of human ABCA8. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.5%BSA and 50% glycerol. |
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以下是关于ABCA8抗体的3篇参考文献示例(注：以下内容为模拟生成，实际文献需通过学术数据库检索确认)：
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1. **文献名称**: *ABCA8 Expression in Human Macrophages: Regulation by Cholesterol and Inflammatory Cytokines*
**作者**: Smith J, et al.
**摘要**: 研究探讨ABCA8蛋白在巨噬细胞中的表达及其与胆固醇代谢的关系。作者使用特异性ABCA8抗体证实其在泡沫细胞中的上调表达，并发现炎症因子TNF-α可抑制其表达，提示ABCA8可能在动脉粥样硬化中发挥作用。
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2. **文献名称**: *Development of a Monoclonal Antibody Against Human ABCA8 for Cancer Biomarker Studies*
**作者**: Lee H, et al.
**摘要**: 该研究报道了一种针对人ABCA8蛋白的单克隆抗体的开发与验证。通过免疫印迹和免疫组化实验，证明该抗体能特异性识别ABCA8.并在乳腺癌组织中检测到ABCA8的异常表达，提示其作为癌症生物标志物的潜力。
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3. **文献名称**: *ABCA8-Mediated Lipid Transport in the Blood-Brain Barrier: Insights from Knockout Mice and Antibody-Based Localization*
**作者**: Garcia R, et al.
**摘要**: 利用ABCA8基因敲除小鼠及特异性抗体，研究揭示了ABCA8在血脑屏障内皮细胞中的定位及其参与鞘脂类转运的功能。抗体染色结果显示，ABCA8缺失导致小鼠脑部脂质代谢异常，可能与神经退行性疾病相关。
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建议通过PubMed或Google Scholar搜索关键词“ABCA8 antibody”获取真实文献。如需具体文献协助，可提供更多背景信息。
The ABCA8 antibody targets the ATP-binding cassette subfamily A member 8 (ABCA8), a transmembrane protein belonging to the ABC transporter superfamily, which facilitates the transport of various substrates, including lipids, sterols, and metabolites, across cellular membranes. ABCA8 is encoded by the *ABCA8* gene located on human chromosome 17q24 and is expressed in tissues such as the liver, placenta, and heart. Though its precise physiological role remains under investigation, ABCA8 is implicated in lipid homeostasis, cholesterol efflux, and cell membrane maintenance, with potential links to diseases like atherosclerosis, cancer, and neurological disorders.
ABCA8 antibodies are essential tools for studying the protein's expression, localization, and function. They are commonly used in techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to detect ABCA8 in biological samples. Polyclonal and monoclonal antibodies against ABCA8 are generated using immunogenic peptide sequences derived from specific regions of the protein, ensuring target specificity. Recent studies suggest ABCA8 may influence drug resistance in cancer by modulating lipid transport, highlighting its therapeutic relevance. However, research on ABCA8 lags behind other ABC transporters (e.g., ABCA1 or ABCG2), necessitating further exploration of its mechanisms and interactions. Validated ABCA8 antibodies are critical for elucidating its role in health and disease, aiding potential diagnostic or therapeutic advancements.
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