Mouse Monoclonal HAO1 Antibody

The HAO1 antibody targets hydroxyacid oxidase 1 (HAO1), a peroxisomal enzyme encoded by the HAO1 gene in humans. HAO1 primarily catalyzes the oxidation of glycolate to glyoxylate and L-pipecolic acid to Δ1-piperideine-6-carboxylate, playing a critical role in glyoxylate and lysine metabolism. Dysregulation of HAO1 is linked to metabolic disorders, particularly primary hyperoxaluria type 3 (PH3), where mutations in HAO1 lead to excessive glyoxylate production, promoting calcium oxalate crystal deposition in kidneys and resulting in nephrolithiasis or renal failure. HAO1 antibodies are essential tools for studying HAO1 expression, localization, and function in both physiological and pathological contexts. They are widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to investigate HAO1's role in cellular metabolism, disease mechanisms, and potential therapeutic strategies. Recent studies also explore HAO1's involvement in cancer progression, as altered HAO1 expression has been observed in certain tumors. Commercially available HAO1 antibodies are typically raised in rabbits or mice, validated for specificity, and applied in preclinical research to advance understanding of metabolic pathways and develop targeted treatments for HAO1-associated disorders.