| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | NIAM; TB-5 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Full length fusion protein |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于TBRG1抗体的参考文献示例(注：部分文献为模拟示例，建议通过学术数据库核实具体内容)：
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1. **文献名称**: "TBRG1 regulates cell cycle progression through TGF-β signaling in cancer cells"
**作者**: Smith A, et al.
**摘要**: 本研究利用特异性TBRG1抗体进行Western blot和免疫荧光实验，发现TBRG1通过调控TGF-β信号通路抑制癌细胞周期进程，其表达水平与细胞增殖呈负相关。
2. **文献名称**: "TBRG1 as a novel biomarker in gastric cancer: Immunohistochemical analysis"
**作者**: Zhang L, et al.
**摘要**: 通过商业化TBRG1抗体对胃癌组织进行免疫组化分析，发现TBRG1蛋白高表达与患者预后不良显著相关，提示其可能作为潜在诊断标志物。
3. **文献名称**: "Functional interaction between TBRG1 and SMAD4 in transcriptional regulation"
**作者**: Garcia R, et al.
**摘要**: 使用TBRG1抗体进行免疫共沉淀实验，证实TBRG1与SMAD4直接结合，协同调控TGF-β依赖性基因转录，影响细胞分化过程。
4. **文献名称**: "TBRG1 modulates neuronal development via protein stability control"
**作者**: Lee H, et al.
**摘要**: 在小鼠神经元模型中，通过TBRG1抗体检测蛋白定位，发现TBRG1通过调控泛素-蛋白酶体系统维持关键神经发育因子的稳定性。
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**备注**：以上文献为示例性质，实际文献请通过PubMed、Google Scholar等平台以关键词“TBRG1 antibody”或“TBRG1 protein function”检索，并核实作者及摘要内容。
TBRG1 (Transforming Growth Factor Beta Regulated Gene 1) antibody is a tool used to study the protein encoded by the TBRG1 gene, which is regulated by TGF-β signaling. TBRG1. also known as FAM77A, plays roles in cell cycle regulation, proliferation, and differentiation. It acts as a downstream mediator of TGF-β-induced growth arrest by stabilizing p21. a cyclin-dependent kinase inhibitor, thereby promoting cell cycle exit. This protein is ubiquitously expressed but shows elevated levels in tissues like the brain, heart, and skeletal muscle.
TBRG1 antibodies are widely employed in research to investigate its expression patterns, subcellular localization (primarily nuclear), and interactions in pathways linked to cancer, fibrosis, and immune regulation. They are utilized in techniques such as Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF). Studies using these antibodies have linked TBRG1 dysregulation to tumor progression, neurodevelopmental disorders, and fibrotic diseases, highlighting its dual role as a tumor suppressor or promoter depending on cellular context.
Structurally, TBRG1 contains conserved phosphorylation sites and a nuclear localization signal. Antibodies targeting specific epitopes help dissect post-translational modifications impacting its function. Most commercial TBRG1 antibodies are raised in rabbits or mice, validated for specificity via knockout controls. Their application advances understanding of TGF-β signaling crosstalk with pathways like MAPK and PI3K/AKT, offering insights into therapeutic targeting in diseases like glioblastoma and pulmonary fibrosis.
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