| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 1/200 | Human,Mouse,Rat |
| IHC | 1/50-300 | Human,Mouse,Rat |
| ICC | 1/200 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| WB Predicted band size | 48kDa |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于CK17 Mouse抗体的3篇参考文献，简要列举如下：
1. **文献名称**: *"Cytokeratin 17 in Breast Cancer: A Review"*
**作者**: Smith A, et al.
**摘要**: 该研究利用小鼠单克隆抗体通过免疫组化分析CK17在乳腺癌组织中的表达，发现CK17与三阴性乳腺癌亚型显著相关，提示其作为潜在诊断标志物的价值。
2. **文献名称**: *"CK17 as a Prognostic Marker in Cervical Squamous Cell Carcinoma"*
**作者**: Lee J, et al.
**摘要**: 通过小鼠抗CK17抗体检测宫颈鳞癌样本，发现CK17高表达与HPV感染及患者不良预后相关，支持其在临床分层中的应用。
3. **文献名称**: *"Cytokeratin 17 Expression Correlates with Pancreatic Ductal Adenocarcinoma Progression"*
**作者**: Wang Y, et al.
**摘要**: 研究使用小鼠来源的CK17抗体进行Western blot和免疫荧光实验，证实CK17在胰腺导管腺癌中高表达，并与肿瘤侵袭性和化疗耐药性相关。
4. **文献名称**: *"Immunohistochemical Analysis of CK17 in Cutaneous Disorders"*
**作者**: Brown K, et al.
**摘要**: 该文献比较了小鼠抗CK17抗体在银屑病和皮肤鳞状细胞癌中的染色模式，表明CK17可作为区分炎症性皮肤病与恶性肿瘤的辅助指标。
(注：以上文献信息为模拟示例，实际引用需以具体数据库检索结果为准。)
CK17 (Cytokeratin 17) is a type I intermediate filament protein encoded by the *KRT17* gene, primarily expressed in basal epithelial cells and certain glandular or stratified epithelia. It plays a structural role in maintaining cellular integrity and is involved in wound healing, cell migration, and stress response. CK17 is notably upregulated in pathological conditions, including squamous cell carcinomas, breast cancer, cervical neoplasia, and psoriasis, making it a biomarker for aggressive tumor behavior and poor prognosis.
The CK17 mouse antibody is a monoclonal antibody generated by immunizing mice with recombinant CK17 protein or specific peptide sequences. It is widely used in research and diagnostics to detect CK17 expression in formalin-fixed, paraffin-embedded (FFPE) tissues or frozen sections via immunohistochemistry (IHC), immunofluorescence (IF), or Western blotting. Its high specificity and affinity allow precise localization of CK17 in epithelial tissues, aiding in distinguishing hyperproliferative or malignant cells from normal counterparts.
This antibody has become critical in studying epithelial-mesenchymal transition (EMT), tumor microenvironment interactions, and therapeutic targeting. Commercial versions often include validation data (e.g., knockout cell line controls) to ensure reliability. Researchers also utilize it to explore CK17's role in inflammatory skin disorders and its potential as a diagnostic marker in precision oncology.
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