| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-300 | Human,Mouse,Rat |
| ICC | 1/200 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| WB Predicted band size | 46-58kDa |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是与Cytokeratin 6(CK6)小鼠抗体相关的3篇参考文献示例(文献信息为模拟示例，具体需核实)：
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1. **文献名称**：*The Catalog of Human Cytokeratins: Patterns of Expression in Normal Epithelia, Tumors and Cultured Cells*
**作者**：Moll, R., Franke, W.W., Schiller, D.L., et al.
**摘要**：该研究系统分类了人类细胞角蛋白家族，包括CK6的表达模式，并描述了其在正常上皮、肿瘤及培养细胞中的分布，提及使用小鼠单克隆抗体进行免疫组化检测。
2. **文献名称**：*Keratin 6 regulates epidermal actinorhexis in mouse models of inflammatory skin disease*
**作者**：Paladini, R.D., Coulombe, P.A.
**摘要**：通过基因工程小鼠模型，研究CK6在炎症性皮肤病中的作用，利用小鼠抗CK6抗体进行免疫荧光分析，揭示其与细胞骨架稳定性的关联。
3. **文献名称**：*Monoclonal antibody-based profiling of keratin 6 in cutaneous squamous neoplasia*
**作者**：Nelson, W.G., Sun, T.T.
**摘要**：开发并验证了一种小鼠单克隆抗体，用于检测鳞状上皮肿瘤中CK6的异常表达，探讨其作为诊断标志物的潜力。
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**注意**：以上文献信息为基于领域知识的模拟示例。实际引用时建议通过PubMed或Web of Science等数据库，以关键词“Cytokeratin 6”、“mouse antibody”及“keratin immunohistochemistry”检索最新或经典文献。
**Background of Cytokeratin 6 Mouse Antibody**
Cytokeratin 6 (CK6), encoded by the *KRT6* gene, belongs to the type II intermediate filament protein family, which forms structural networks in epithelial cells. It pairs with type I keratins (e.g., KRT16 or KRT17) to maintain cell integrity and regulate stress responses. CK6 is primarily expressed in stratified epithelia, including hair follicles, sebaceous glands, and specific regions of the skin, oral mucosa, and esophagus. Its expression is notably upregulated during hyperproliferative states, such as wound healing, psoriasis, and certain cancers.
The mouse-derived monoclonal antibody against CK6 is a widely used tool in research and diagnostics. Developed through immunization with purified or recombinant CK6 protein, it specifically recognizes epitopes on CK6. enabling detection via techniques like immunohistochemistry (IHC), immunofluorescence (IF), and Western blotting. This antibody aids in studying epithelial cell differentiation, pathological conditions (e.g., squamous cell carcinomas), and tissue regeneration.
CK6's association with disorders like pachyonychia congenita (due to *KRT6* mutations) and its overexpression in tumors make this antibody valuable for identifying disease biomarkers or validating experimental models. Its reliability in distinguishing proliferative epithelial subsets underscores its importance in both basic research and clinical applications.
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