Rabbit Polyclonal CWC27 Antibody

The CWC27 antibody is a research tool targeting the CWC27 protein, a component of the spliceosome complex involved in pre-mRNA splicing. CWC27 (CWC27 spliceosome-associated protein) plays a critical role in maintaining spliceosome integrity and regulating alternative splicing events. Dysregulation of CWC27 has been linked to human diseases, particularly retinal degeneration and ciliopathies. Mutations in the CWC27 gene are associated with autosomal recessive retinitis pigmentosa (RP64) and syndromic disorders featuring retinal dystrophy, skeletal abnormalities, and ciliary dysfunction. Studies in model organisms, such as mice, show that CWC27 deficiency disrupts cilia formation and Hedgehog signaling pathways, highlighting its role in cellular and developmental processes. The CWC27 antibody is widely used in molecular biology applications, including Western blotting, immunofluorescence, and immunohistochemistry, to investigate its expression, localization, and interactions in tissues and cell lines. It serves as a key reagent for exploring disease mechanisms, validating gene-editing models, and identifying biomarkers for cilia-related pathologies. Research on CWC27 continues to advance understanding of spliceosome biology and its implications in genetic disorders, offering potential therapeutic targets for conditions linked to splicing defects or ciliary dysfunction.