Rabbit Polyclonal NUCB2 Antibody

The NUCB2 antibody targets nucleobindin-2 (NUCB2), a protein encoded by the *NUCB2* gene, which is widely expressed in central and peripheral tissues. NUCB2 is the precursor of nesfatin-1. a neuropeptide implicated in regulating appetite, energy homeostasis, and glucose metabolism. Initially identified as a hypothalamic satiety molecule, nesfatin-1 has since been linked to diverse physiological processes, including stress response, cardiovascular function, and reproductive regulation. NUCB2 antibodies are critical tools for detecting and quantifying NUCB2/nesfatin-1 in research settings, enabling studies of its tissue distribution, secretion dynamics, and molecular interactions. These antibodies are commonly used in techniques like Western blotting, immunohistochemistry, and ELISA across models ranging from cell lines to animal tissues. Due to NUCB2's conserved structure in mammals, antibodies often exhibit cross-species reactivity, facilitating translational research. Recent studies highlight NUCB2/nesfatin-1's potential roles in metabolic disorders (e.g., obesity, diabetes), neurodegenerative diseases, and cancer, driving demand for validated antibodies. Researchers prioritize antibodies verified for specificity through knockout controls or blocking peptides to ensure accurate data. As interest grows in NUCB2's dual intracellular and extracellular signaling mechanisms, high-quality antibodies remain essential for unraveling its pathophysiological significance and therapeutic potential.