| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Hbeta4; K(VCA)beta-4; KCMB4; KCNMB4; Slo-beta-4 |
| Entrez GeneID | 27345; |
| WB Predicted band size | 24kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse |
| Immunogen | Synthetic peptide corresponding to residues near the N terminal of human potassium large conductance calcium-activated channel, subfamily M, beta member 4 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是3篇关于KCNMB4抗体的参考文献及其摘要内容(基于近年研究整理，部分为示例性简化内容)：
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1. **文献名称**: "Differential Expression of KCNMB4 in Human Gliomas and Its Role in Tumor Cell Proliferation"
**作者**: Smith A, et al.
**摘要**: 本研究通过Western blot和免疫组化使用KCNMB4抗体，发现其在高级别胶质瘤中表达显著下调。实验表明KCNMB4通过调控BK通道活性抑制肿瘤细胞增殖，提示其可能作为神经胶质瘤的潜在治疗靶点。
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2. **文献名称**: "KCNMB4 Modulates BK Channel Activation in Vascular Smooth Muscle"
**作者**: Chen L, et al.
**摘要**: 研究利用KCNMB4特异性抗体进行共聚焦显微镜定位，证实该亚基在血管平滑肌细胞膜上富集。功能实验显示KCNMB4通过改变BK通道对钙离子的敏感性参与血压调节，为高血压机制研究提供新方向。
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3. **文献名称**: "Antibody-Based Profiling of KCNMB4 in Alzheimer’s Disease Brain Tissues"
**作者**: Gonzalez R, et al.
**摘要**: 通过免疫印迹和免疫荧光技术，作者发现阿尔茨海默病患者脑组织中KCNMB4蛋白水平异常升高，且与β淀粉样蛋白沉积区域共定位。提示KCNMB4可能参与神经退行性病变的离子通道失调过程。
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*注：以上文献为基于真实研究的模拟示例，实际文献需通过PubMed/Google Scholar检索确认。如需具体文章，建议使用关键词“KCNMB4 antibody” + “expression/function/disease”查询近年论文数据库。*
The KCNMB4 antibody is a tool used to detect the KCNMB4 protein, a regulatory subunit of calcium-activated potassium (BK) channels. These channels, integral to cellular processes like membrane potential regulation and calcium signaling, are composed of pore-forming α-subunits (KCNMA1) and modulatory β-subunits (KCNMB1-4). KCNMB4. specifically, is a member of the β4 subfamily and is predominantly expressed in the brain, where it fine-tunes BK channel activity by slowing activation kinetics and reducing calcium sensitivity. This unique modulation impacts neuronal excitability, neurotransmitter release, and synaptic plasticity.
KCNMB4 antibodies are essential in studying the protein's expression patterns, interactions, and functional roles in physiological and pathological contexts. Research has linked KCNMB4 dysregulation to neurological disorders, including epilepsy and schizophrenia, as well as certain cancers. Commercially available antibodies (polyclonal or monoclonal) are validated for applications like Western blotting, immunohistochemistry, and immunofluorescence. Specificity is critical due to structural similarities among β-subunits, necessitating rigorous validation via knockout controls or peptide-blocking assays.
Overall, the KCNMB4 antibody serves as a key reagent for unraveling BK channel diversity and its implications in disease mechanisms, offering insights into targeted therapeutic strategies.
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