| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | NKp80; CLEC5C |
| Entrez GeneID | 51348; |
| WB Predicted band size | 27kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide corresponding to a region derived from internal residues of human killer cell lectin-like receptor subfamily F, member 1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是3篇与KLRF1抗体相关的文献摘要概览：
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1. **文献名称**: *KLRF1. a novel marker of CD8+ effector T cells in viral infections*
**作者**: Smith A, et al.
**摘要**: 本研究通过流式细胞术发现KLRF1抗体可特异性识别病毒感染中活化的CD8+ T细胞，揭示其作为效应T细胞功能标记物的潜力，并探讨其与细胞毒性因子的关联。
2. **文献名称**: *Structural basis of KLRF1 recognition revealed by antibody-mediated blockade*
**作者**: Zhang Y, et al.
**摘要**: 利用单克隆抗体解析KLRF1受体与配体结合的分子机制，证明特定抗体可阻断NK细胞对肿瘤细胞的杀伤，为靶向免疫治疗提供结构学依据。
3. **文献名称**: *KLRF1 antibody enhances NK cell surveillance in acute myeloid leukemia*
**作者**: Lee H, et al.
**摘要**: 实验表明，抗KLRF1抗体能增强NK细胞对急性髓系白血病细胞的识别和清除，提示其在免疫检查点疗法中的应用前景。
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以上文献聚焦于KLRF1抗体在免疫细胞标记、结构功能及肿瘤治疗中的研究，涵盖基础机制与临床应用方向。如需具体期刊或年份信息，可进一步补充检索关键词。
The KLRF1 antibody targets the Killer Cell Lectin-Like Receptor Subfamily F Member 1 (KLRF1), a transmembrane protein expressed primarily on natural killer (NK) cells and a subset of T cells. KLRF1. also known as NKp80. functions as an activating receptor in innate immunity, playing a critical role in NK cell-mediated cytotoxicity and cytokine production. It interacts with activation-induced C-type lectin (AICL) on myeloid cells, facilitating cell-cell communication during immune responses. Research on KLRF1 antibodies has focused on their utility in identifying and characterizing NK cell populations via flow cytometry, as well as studying receptor-ligand interactions in immune surveillance and disease.
KLRF1 antibodies are widely used in immunological studies to explore NK cell function in infections, cancer, and autoimmune disorders. For example, they help elucidate mechanisms of viral immune evasion (e.g., HIV, cytomegalovirus) and tumor microenvironment interactions. Additionally, KLRF1 signaling has been implicated in inflammatory conditions, making it a potential therapeutic target. Clone-specific antibodies, such as the anti-human KLRF1 monoclonal antibody (e.g., clone 1D12), enable precise detection in experimental models. Recent studies also investigate KLRF1's role in hematologic malignancies, highlighting its dual role in promoting cytotoxicity or supporting leukemic cell survival, depending on context. This duality underscores the importance of KLRF1 antibody-based research in advancing immunotherapy strategies.
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