| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | PAC1; PAC-1 |
| Entrez GeneID | 1844; |
| WB Predicted band size | 34kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse |
| Immunogen | Synthetic peptide corresponding to residues near the C terminal of human dual specificity phosphatase 2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于DUSP2抗体的3篇参考文献示例(注：以下内容为虚构模拟，仅作格式参考)：
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1. **文献名称**：*DUSP2 Regulates Inflammatory Responses in Macrophages via MAPK Signaling*
**作者**：Zhang L, et al.
**摘要**：本研究利用DUSP2特异性抗体，通过Western blot和免疫荧光技术，揭示了DUSP2在巨噬细胞中通过去磷酸化p38和JNK调控炎症因子分泌的机制。结果显示，DUSP2缺失会加剧LPS诱导的炎症反应。
2. **文献名称**：*Role of DUSP2 in Tumor Suppression: Insights from Immunohistochemical Analysis*
**作者**：Chen X, et al.
**摘要**：通过免疫组化(IHC)结合DUSP2抗体，研究团队发现DUSP2在结直肠癌组织中表达显著下调，且低表达与患者预后不良相关。实验进一步证明DUSP2通过抑制ERK信号通路抑制肿瘤细胞增殖。
3. **文献名称**：*DUSP2 Antibody-Based Detection of Oxidative Stress-Induced Protein Modulation*
**作者**：Smith J, et al.
**摘要**：本文开发了一种高特异性DUSP2兔多克隆抗体，验证了其在流式细胞术和ELISA中的应用。研究发现，氧化应激条件下DUSP2在内皮细胞中的表达动态变化，提示其参与细胞应激应答。
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**说明**：以上文献为示例性内容，实际文献需通过PubMed、Google Scholar等平台检索关键词“DUSP2 antibody”“DUSP2 function”等获取。真实研究可能涉及DUSP2在免疫调节、癌症或代谢疾病中的具体机制及抗体应用场景。
The DUSP2 antibody is a crucial tool for studying dual-specificity phosphatase 2 (DUSP2), a member of the MAP kinase phosphatase (MKP) family. DUSP2. also known as PAC-1. regulates mitogen-activated protein kinase (MAPK) signaling by dephosphorylating ERK, JNK, and p38. thereby modulating cellular responses like proliferation, differentiation, and apoptosis. It is predominantly expressed in immune cells, including macrophages and T-cells, and plays a role in inflammatory responses and immune regulation. Dysregulation of DUSP2 has been linked to autoimmune diseases, cancer, and metabolic disorders, highlighting its therapeutic potential.
The DUSP2 antibody enables researchers to detect and quantify DUSP2 protein levels in techniques such as Western blotting, immunohistochemistry, and flow cytometry. It is essential for investigating DUSP2’s spatial-temporal expression, post-translational modifications, and interactions within signaling networks. Validated antibodies are typically raised in hosts like rabbits or mice, with specificity confirmed via knockout controls or siRNA knockdown. Commercial antibodies often include datasheets detailing applications, species reactivity, and storage conditions.
Research using DUSP2 antibodies has revealed its role in dampening MAPK-driven inflammation and its dual function as a tumor suppressor or promoter, depending on cellular context. Studies in disease models, such as rheumatoid arthritis or colorectal cancer, underscore its importance in pathophysiology. Reliable DUSP2 antibodies remain vital for dissecting its biological functions and exploring targeted therapies.
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