| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/15-1/50 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | DRCC1; MUC-13 |
| Entrez GeneID | 56667; |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide corresponding to residues near the C terminal of human mucin 13, cell surface associated |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于MUC13抗体的3篇代表性文献的简要信息(示例基于公开研究趋势，建议通过学术数据库核实具体内容)：
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1. **文献名称**：*MUC13 promotes colorectal cancer development via activating the Wnt/β-catenin signaling pathway*
**作者**：Sheng YH, et al.
**摘要**：本研究开发了针对MUC13蛋白的单克隆抗体，发现其在结直肠癌组织中高表达，并通过激活Wnt/β-catenin通路促进肿瘤增殖和转移。抗体被用于免疫组化验证MUC13的临床相关性。
2. **文献名称**：*A novel anti-MUC13 antibody-drug conjugate for targeting pancreatic cancer*
**作者**：Ganesan S, et al.
**摘要**：研究团队设计了一种靶向MUC13的抗体-药物偶联物(ADC)，在胰腺癌模型中显示出特异性杀伤肿瘤细胞的效果，表明MUC13抗体在靶向治疗中的潜在应用价值。
3. **文献名称**：*MUC13 as a biomarker for gastric cancer: Diagnostic and prognostic evaluation using immunohistochemistry*
**作者**：Li C, et al.
**摘要**：通过抗MUC13抗体的免疫组化分析，发现MUC13在胃癌组织中的过表达与患者预后不良显著相关，提示其作为诊断标志物和预后评估工具的潜力。
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**注意**：以上为示例性内容，实际文献需通过PubMed、Google Scholar等平台检索关键词“MUC13 antibody”或“MUC13 therapeutic target”获取最新研究。近年研究可能聚焦于抗体靶向治疗、表位定位或临床前模型验证。
The MUC13 antibody targets the mucin 13 glycoprotein, a transmembrane mucin belonging to the mucin family, which is characterized by O-glycosylated tandem repeat domains. MUC13 is expressed in epithelial tissues, particularly the gastrointestinal tract, and plays roles in cell adhesion, signaling, and immune modulation. Its aberrant overexpression has been linked to multiple cancers, including colorectal, gastric, pancreatic, and ovarian cancers, where it promotes tumor progression, metastasis, and chemoresistance.
Structurally, MUC13 contains an extracellular mucin domain with variable numbers of tandem repeats, a SEA (sea urchin sperm protein, enterokinase, and agrin) module, a transmembrane domain, and a cytoplasmic tail involved in intracellular signaling. MUC13 interacts with signaling pathways such as EGFR, HER2. and NF-κB, enhancing cell survival and proliferation.
Antibodies against MUC13 are primarily used in research and diagnostics to detect its expression in tissues or biological fluids, aiding in cancer diagnosis, prognosis, and therapeutic targeting. Studies suggest MUC13 as a potential biomarker for early detection and a therapeutic target, with antibodies enabling investigations into its role in tumor microenvironments and resistance mechanisms. Recent efforts also explore its utility in antibody-drug conjugates or immune-based therapies. However, clinical applications remain under investigation, necessitating further validation of MUC13's functional mechanisms and therapeutic potential.
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