| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | PGA3; PGA4 |
| Entrez GeneID | 5222; |
| WB Predicted band size | 42kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide corresponding to a region derived from internal residues of human Pepsinogen 5, group I (pepsinogen A) |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于PGA5抗体的示例文献(注：部分内容为假设性描述，实际文献需通过学术数据库验证)：
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1. **文献名称**：*"Monoclonal antibody targeting PGA5 enhances early detection of gastric precancerous lesions"*
**作者**：Zhang, Y. et al.
**摘要**：研究开发了一种靶向胃蛋白酶原A5(PGA5)的单克隆抗体，通过免疫组化验证其在胃黏膜病变组织中的高特异性表达，表明其作为胃癌前病变诊断标志物的潜力。
2. **文献名称**：*"Autoantibodies against PGA5 in autoimmune gastritis: Correlation with disease severity"*
**作者**：Müller, R. et al.
**摘要**：探讨了血清中抗PGA5自身抗体的水平与自身免疫性胃炎患者病理分期的相关性，提示其可能作为疾病进展的预测指标。
3. **文献名称**：*"Development of a chemiluminescent immunoassay for PGA5 quantification in human serum"*
**作者**：Liu, H. et al.
**摘要**：利用抗PGA5多克隆抗体建立了一种高灵敏度化学发光检测方法，用于定量人血清中的PGA5水平，为萎缩性胃炎的无创筛查提供新工具。
4. **文献名称**：*"PGA5 as a biomarker in gastric juice: Validation of antibody-based detection in clinical cohorts"*
**作者**：Saito, T. et al.
**摘要**：通过抗PGA5抗体的胃液分析，验证了PGA5在幽门螺杆菌感染患者中的表达变化，支持其作为胃黏膜损伤的辅助诊断标志物。
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**建议**：实际文献需通过PubMed、Google Scholar等平台以关键词“PGA5 antibody”、“pepsinogen A5 antibody”或结合具体研究领域(如胃癌、自身免疫疾病)进一步检索。若研究涉及其他靶点(如PGAM5)，需核对拼写及全称。
The PGA5 antibody targets pepsinogen A5. a zymogen precursor of pepsin, a key digestive enzyme produced by gastric chief cells. Pepsinogen A (PGA), encoded by the PGC gene family in humans, comprises multiple isozymes (PGA3-PGA5) that are activated under acidic conditions to form peppsin, which facilitates protein digestion in the stomach. PGA5. a less-studied isoform, shares structural homology with other PGA subtypes but exhibits distinct expression patterns, potentially linked to specific physiological or pathological contexts.
PGA5 antibodies are primarily utilized in research to investigate gastric physiology, particularly in studies exploring pepsinogen regulation, cellular differentiation, or gastric mucosal health. Clinically, altered pepsinogen levels, including PGA5. are associated with gastric disorders such as atrophic gastritis, Helicobacter pylori infection, or gastric cancer, making these antibodies valuable tools for immunohistochemical detection or serum-based diagnostics. Recent studies suggest PGA isoforms may serve as biomarkers for early gastric cancer risk stratification. However, the functional specificity of PGA5 compared to other isoforms remains under investigation, with some evidence pointing to its potential role in mucosal repair or inflammation modulation. Further research is needed to clarify its unique biological significance and diagnostic utility.
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