| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | ANKRA |
| Entrez GeneID | 57763; |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide corresponding to residues near the C terminal of human ankyrin repeat, family A (RFXANK-like), 2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下为假设性参考文献示例(仅供参考，实际文献需通过学术数据库检索确认)：
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1. **"ANKRA2 interacts with HDAC3 to modulate nuclear receptor-mediated transcription"**
*作者：Smith A, et al. (2015)*
**摘要**：本研究利用ANKRA2特异性抗体进行免疫共沉淀(Co-IP)实验，揭示了ANKRA2通过结合组蛋白去乙酰化酶HDAC3.调控核受体(如GR和AR)的转录活性，提示其在表观遗传调控中的关键作用。
2. **"ANKRA2 regulates megakaryocyte differentiation via BMP signaling"**
*作者：Chen L, et al. (2018)*
**摘要**：通过Western blot和免疫荧光技术(使用ANKRA2抗体)，研究发现ANKRA2通过调控BMP/Smad通路影响巨核细胞分化，为血小板生成异常的机制提供了新见解。
3. **"Prognostic significance of ANKRA2 expression in prostate cancer"**
*作者：Kim J, et al. (2020)*
**摘要**：通过免疫组化(IHC)分析ANKRA2在前列腺癌组织中的表达水平，发现其低表达与肿瘤转移和不良预后相关，提示ANKRA2可能作为潜在生物标志物。
4. **"ANKRA2 deficiency promotes cardiac hypertrophy through MAPK signaling"**
*作者：Garcia R, et al. (2021)*
**摘要**：利用ANKRA2敲除小鼠模型及抗体检测技术，证实ANKRA2缺失通过激活MAPK通路导致病理性心脏肥大，为其在心血管疾病中的作用提供证据。
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**提示**：实际研究中，ANKRA2抗体的应用多集中于机制探索(如蛋白互作、信号通路)或疾病标记物分析。建议通过PubMed或Google Scholar以“ANKRA2 antibody”和特定研究领域(如癌症、表观遗传)为关键词检索最新文献。
The ANKRA2 (Ankyrin Repeat Family A Member 2) antibody is a tool used to detect and study the ANKRA2 protein, a nuclear protein implicated in transcriptional regulation and chromatin remodeling. ANKRA2 contains multiple ankyrin repeats, structural motifs that mediate protein-protein interactions, enabling its role in scaffolding and recruiting molecular complexes. It interacts with key partners like histone deacetylases (HDACs) and the androgen receptor (AR), positioning it as a regulator of gene expression and cellular differentiation.
Research highlights ANKRA2’s involvement in modulating the AR signaling pathway, which is critical in prostate cancer progression. It also associates with Megator, a nuclear pore-associated protein, suggesting roles in nuclear organization and mitotic regulation. Dysregulation of ANKRA2 has been linked to cancer, immune responses, and developmental processes, making it a potential biomarker or therapeutic target.
The ANKRA2 antibody, often raised in rabbits or mice, is validated for applications like Western blotting, immunoprecipitation, and immunofluorescence. Its specificity helps elucidate ANKRA2’s expression patterns, subcellular localization, and molecular interactions in both normal and pathological contexts. Ongoing studies aim to clarify its dual roles as a tumor suppressor or oncogene, depending on cellular context, and its broader impact on epigenetic regulation and disease mechanisms.
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