| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | MRP5; SMRP; ABC33; MOATC; MOAT-C; pABC11; EST277145 |
| Entrez GeneID | 10057; |
| WB Predicted band size | 161kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse |
| Immunogen | Synthetic peptide corresponding to residues near the N terminal of human ATP-binding cassette, sub-family C? |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于ABCC5抗体的3篇代表性文献的简要信息(注：文献为示例性概括，非真实存在)：
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1. **文献名称**：*ABCC5-mediated drug resistance in glioblastoma: Role of antibody-based detection*
**作者**：Chen L. et al.
**摘要**：研究利用特异性ABCC5抗体，发现其在胶质母细胞瘤中高表达，并与替莫唑胺化疗耐药性相关。抗体染色显示ABCC5定位于细胞膜，提示其可能通过外排药物降低疗效。
2. **文献名称**：*Characterization of ABCC5 antibody specificity in neurological disorders*
**作者**：Wang Y. et al.
**摘要**：通过免疫印迹和免疫组化验证了一种高特异性ABCC5抗体的可靠性，发现ABCC5在阿尔茨海默病患者脑组织中表达上调，可能与β-淀粉样蛋白清除通路相关。
3. **文献名称**：*ABCC5 as a biomarker in colorectal cancer: Validation via monoclonal antibody*
**作者**：Rodriguez S. et al.
**摘要**：开发了一种靶向ABCC5的单克隆抗体，证实其在结直肠癌组织中的表达与5-FU化疗敏感性呈负相关，提示ABCC5可作为预后标志物。
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以上内容基于ABCC5已知功能(如药物外排、癌症耐药性)的合理推测，实际文献需通过PubMed或Google Scholar检索确认。
ABCC5 (ATP-binding cassette subfamily C member 5), also known as multidrug resistance-associated protein 5 (MRP5), is a transmembrane transporter protein belonging to the ATP-binding cassette (ABC) superfamily. It facilitates the efflux of a broad range of endogenous and exogenous substrates, including cyclic nucleotides (cAMP/cGMP), antiviral agents, and anticancer drugs, contributing to cellular detoxification and drug resistance. ABCC5 is widely expressed in tissues such as the liver, kidneys, brain, and blood-brain barrier, playing roles in nucleotide homeostasis, cellular signaling, and drug pharmacokinetics. Dysregulation of ABCC5 has been implicated in cancer chemoresistance, neurological disorders, and cardiovascular diseases.
Antibodies targeting ABCC5 are essential tools for studying its expression, localization, and function. These antibodies are commonly used in techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to detect ABCC5 in cell lines, tissues, or clinical samples. Specificity is validated using knockout controls or siRNA-mediated silencing. Research applications include investigating ABCC5's role in multidrug resistance mechanisms, its interaction with signaling pathways (e.g., cAMP-dependent pathways), and its potential as a therapeutic target. Commercially available ABCC5 antibodies vary in clonality (monoclonal/polyclonal), epitope recognition, and species reactivity (human, mouse, rat), enabling versatile experimental designs. Reliable ABCC5 antibodies are critical for advancing studies in oncology, neurobiology, and pharmacology.
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