Rabbit Polyclonal GRM4 Antibody

The GRM4 antibody is a crucial tool for studying the metabotropic glutamate receptor 4 (mGluR4), a class C G protein-coupled receptor (GPCR) predominantly expressed in the central nervous system. mGluR4. encoded by the GRM4 gene, plays a key role in modulating synaptic transmission and plasticity by regulating neurotransmitter release, particularly glutamate and GABA. It couples primarily to Gi/o proteins, inhibiting adenylyl cyclase and reducing cAMP levels upon activation. GRM4 is implicated in neurological and psychiatric disorders, including Parkinson’s disease, anxiety, and schizophrenia, making it a therapeutic target. The GRM4 antibody enables researchers to detect, localize, and quantify mGluR4 expression in tissues or cells via techniques like Western blotting, immunohistochemistry, or immunofluorescence. Its specificity is critical for distinguishing mGluR4 from other mGluR subtypes (e.g., mGluR1-8) due to structural similarities. Commercially available GRM4 antibodies are typically raised against peptide sequences unique to the receptor’s extracellular or intracellular domains. Validation includes testing in knockout models or siRNA-treated cells to confirm target specificity. Recent studies using GRM4 antibodies have elucidated its neuroprotective roles, synaptic localization, and interactions with downstream signaling molecules. However, variability in antibody performance across applications remains a challenge, emphasizing the need for rigorous validation in experimental setups.