| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | KFM; KFS; KFS1; KFSL; SGM1; BMP13; CDMP2; MCOP4; SCDO4; MCOPCB6 |
| Entrez GeneID | 392255; |
| WB Predicted band size | 51kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide corresponding to a region derived from internal residues of human growth differentiation factor 6 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
+ +
以下是关于GDF6抗体的3篇文献示例(内容基于公开研究整理，具体文献需通过学术数据库核实)：
1. **"GDF6 regulates cartilage development and repair via BMP signaling"**
*作者：Smith J, et al. (2018)*
摘要：研究通过GDF6特异性抗体阻断实验，揭示GDF6在软骨细胞分化中的作用，并发现其通过调控BMP通路影响关节损伤修复。
2. **"Characterization of a monoclonal antibody targeting GDF6 for skeletal dysplasia research"**
*作者：Lee H, et al. (2020)*
摘要：开发并验证了一种高特异性抗GDF6单克隆抗体，证明其在免疫组化和Western blot中的应用，为骨骼发育异常疾病提供新工具。
3. **"GDF6-mediated signaling in zebrafish embryogenesis"**
*作者：Zhang R, et al. (2016)*
摘要：利用GDF6抗体进行斑马鱼胚胎组织定位分析，发现GDF6在颅面骨和神经嵴细胞迁移中的关键调控作用。
注：以上为模拟示例，实际文献需通过PubMed或Google Scholar检索确认。
The Growth Differentiation Factor 6 (GDF6) antibody is a tool used to detect and study GDF6. a secreted protein belonging to the transforming growth factor-beta (TGF-β) superfamily. GDF6 plays critical roles in embryonic development, particularly in skeletal and joint formation, neurogenesis, and limb patterning. It regulates cell differentiation, tissue morphogenesis, and skeletal homeostasis by signaling through bone morphogenetic protein (BMP) receptors and interacting with intracellular SMAD proteins. Mutations in the GDF6 gene are associated with congenital skeletal malformations, craniofacial defects, and spinal conditions like scoliosis, making it a focus in developmental biology and disease research.
GDF6 antibodies are widely utilized in immunohistochemistry (IHC), Western blot (WB), and immunofluorescence (IF) to localize and quantify GDF6 expression in tissues and cells. These antibodies aid in investigating its role in developmental pathways, degenerative diseases, and regenerative processes. For instance, studies leverage GDF6 antibodies to explore its potential in cartilage repair, neuroprotection, or addressing ocular defects. Commercially available GDF6 antibodies are often validated for specificity using knockout controls or peptide blocking assays. Researchers must verify cross-reactivity and optimize protocols due to similarities among TGF-β family members. Understanding GDF6 dynamics through antibody-based approaches contributes to therapeutic strategies for skeletal disorders and neural pathologies.
×
