| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | FHX |
| Entrez GeneID | 55810; |
| WB Predicted band size | 62kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse |
| Immunogen | Synthetic peptide corresponding to a region derived from internal residues of human forkhead box J2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于FOXJ2抗体的示例参考文献(注：以下内容为模拟示例，部分文献信息可能不完整或为虚构)：
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1. **文献名称**: "FOXJ2 transcription factor is essential for neuronal differentiation and cortical development"
**作者**: Li, Y., et al.
**摘要**: 该研究通过免疫组化和小鼠模型证明FOXJ2在中枢神经系统发育中的关键作用。使用FOXJ2抗体进行Western blot和免疫荧光染色，发现其在神经前体细胞中高表达，敲除FOXJ2导致皮层神经元迁移异常。
2. **文献名称**: "Characterization of a novel monoclonal antibody against human FOXJ2 and its application in cancer research"
**作者**: Zhang, H., et al.
**摘要**: 研究团队开发了一种高特异性的FOXJ2单克隆抗体，并通过质谱和敲低实验验证其可靠性。该抗体被用于检测多种癌症细胞系中FOXJ2的表达水平，结果显示其在胃癌组织中表达显著上调。
3. **文献名称**: "FOXJ2 regulates ciliogenesis in cooperation with other forkhead proteins"
**作者**: Gupta, S., & Wang, X.
**摘要**: 本文利用FOXJ2抗体进行免疫共沉淀(Co-IP)和染色质免疫沉淀(ChIP)，揭示了FOXJ2与其他Fox家族蛋白(如FOXJ1)在纤毛形成中的协同作用，为纤毛相关疾病提供分子机制依据。
4. **文献名称**: "Epigenetic modulation of FOXJ2 expression in hepatocellular carcinoma"
**作者**: Tanaka, K., et al.
**摘要**: 通过免疫组化和甲基化分析，研究发现肝癌组织中FOXJ2启动子高甲基化导致其表达下调。FOXJ2抗体用于验证临床样本中的蛋白表达缺失，提示其作为肿瘤抑制因子的潜在功能。
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**注**：以上文献为示例性内容，实际研究中请通过学术数据库(如PubMed、Web of Science)检索最新且经同行评审的论文。如需具体文献协助，建议提供更详细的研究背景或关键词。
The FOXJ2 antibody is a research tool used to detect and study the Forkhead box J2 (FOXJ2) protein, a member of the Forkhead box (FOX) family of transcription factors. FOXJ2. also known as Forkhead-related activator 2 (FREAC-2), is involved in regulating gene expression by binding to DNA through its conserved forkhead domain. It plays roles in diverse biological processes, including embryonic development, cell differentiation, and tissue homeostasis. Unlike its well-characterized relative FOXJ1 (critical for cilia formation), FOXJ2's functions are less understood, though studies suggest it may influence cell cycle progression, apoptosis, and cancer pathways.
FOXJ2 antibodies are typically produced in hosts like rabbits or mice using immunogenic peptides or recombinant protein fragments. These antibodies enable techniques such as Western blotting, immunohistochemistry (IHC), immunofluorescence (IF), and chromatin immunoprecipitation (ChIP) to investigate FOXJ2's expression patterns, subcellular localization, and interactions. Research has identified FOXJ2 overexpression in certain cancers, including gliomas and breast cancer, hinting at its potential oncogenic role. However, its context-dependent regulatory mechanisms remain under exploration.
Validated FOXJ2 antibodies are essential for elucidating its biological significance and clinical relevance. Commercial antibodies often undergo specificity testing via knockout cell lines or siRNA knockdown. As FOXJ2 research expands, its antibody continues to support studies linking this transcription factor to developmental disorders, tumorigenesis, and other diseases.
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