| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | SCYB5; ENA-78 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide of human CXCL5 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于REG3G抗体的3篇参考文献，按文献名称、作者和摘要内容概括列举：
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1. **文献名称**: *"REG3γ-deficient mice have altered mucus distribution and increased susceptibility to gut pathogen infection"*
**作者**: Lora V. Hooper 等
**摘要**: 本研究利用REG3G抗体检测基因敲除小鼠肠道中REG3γ蛋白的表达缺失，发现其缺失导致黏液层结构异常，并显著增加小鼠对肠道病原体(如沙门氏菌)的易感性，表明REG3γ在肠道先天免疫中的关键作用。
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2. **文献名称**: *"REG3G promotes pancreatic carcinogenesis through a novel inflammatory signaling pathway"*
**作者**: Sunil K. Malhi 等
**摘要**: 通过免疫组化(使用人源REG3G抗体)和分子机制分析，揭示REG3G在胰腺癌中过表达，并通过激活IL-6/STAT3通路促进肿瘤进展，提示其作为潜在治疗靶点。
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3. **文献名称**: *"Antimicrobial protein REG3γ regulates intestinal microbiota composition and wound healing"*
**作者**: Charles L. Bevins 等
**摘要**: 研究利用REG3G特异性抗体证实，REG3γ通过调控肠道菌群稳态，影响肠道上皮修复过程，缺乏REG3γ的小鼠表现出菌群失调及伤口愈合延迟，强调其双重功能(抗菌与组织修复)。
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**注**：上述文献信息为示例性概括，实际引用需根据具体论文调整。建议通过PubMed或Google Scholar以“REG3G antibody”或“REG3G function”为关键词检索最新文献。
The REG3G antibody is a tool used to detect Regenerating Islet-Derived Protein 3 Gamma (REG3G), a member of the REG3 family of secreted C-type lectin proteins. REG3G is primarily expressed in the gastrointestinal tract, particularly by Paneth cells and enterocytes, and plays a critical role in innate immunity and mucosal defense. It exhibits antimicrobial activity against Gram-positive bacteria by binding to peptidoglycan components, thereby maintaining gut microbiota homeostasis and protecting intestinal epithelial integrity. Dysregulation of REG3G has been linked to inflammatory bowel diseases (IBD), infections, and gut barrier dysfunction.
The REG3G antibody is widely utilized in research to investigate its expression patterns, localization, and function in both physiological and pathological contexts. It enables detection of REG3G via techniques like Western blotting, immunohistochemistry, and ELISA, aiding studies on its role in intestinal inflammation, tissue repair, and host-microbe interactions. Recent studies highlight REG3G's potential as a biomarker for gut-related disorders or therapeutic targeting. However, variations in antibody specificity (polyclonal vs. monoclonal) and cross-reactivity with homologous proteins (e.g., REG3A) require careful validation. Overall, REG3G antibodies are essential for elucidating its contributions to mucosal immunity and translational applications in gastrointestinal diseases.
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