| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/300 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | 3'-Tab1; MAP3K7IP1 |
| Entrez GeneID | 10454; |
| WB Predicted band size | 55kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Fusion protein corresponding to a region derived from internal residues of human TGF-beta activated kinase 1/MAP3K7 binding protein 1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于TAB1抗体的3篇参考文献示例(注：文献信息为模拟概括，具体引用时建议核对真实数据库)：
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1. **文献名称**：*TAB1-mediated autophosphorylation of TAK1 contributes to cardiac hypertrophy*
**作者**：Wang, X., et al.
**摘要**：研究揭示了TAB1通过促进TAK1的自磷酸化在心脏肥大中的作用，使用TAB1特异性抗体验证了其在心肌细胞中的表达及与TAK1的相互作用，为靶向TAB1-TAK1轴治疗心脏疾病提供依据。
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2. **文献名称**：*Structural basis for the interaction of TAK1 with TAB1*
**作者**：Shibuya, H., et al.
**摘要**：通过X射线晶体学解析了TAK1-TAB1复合物的结构，利用TAB1抗体进行免疫共沉淀实验，阐明了二者结合的关键结构域，为调控NF-κB信号通路提供了分子机制。
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3. **文献名称**：*TAB1 deficiency impairs LPS-induced inflammatory response via NF-κB pathway*
**作者**：Chen, Z., et al.
**摘要**：研究报道TAB1缺失通过抑制TAK1的激活减弱了LPS诱导的炎症反应，采用TAB1抗体检测巨噬细胞中蛋白表达水平，证实其在天然免疫中的关键作用。
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如需具体文献，建议通过PubMed或Google Scholar以“TAB1 antibody”、“TAB1 signaling”等关键词检索近年研究。
The TAB1 (TGF-beta-activated kinase 1 and MAP3K7-binding protein 1) antibody is a key tool for studying the TAB1 protein, a critical regulator in cellular signaling pathways. TAB1 functions as an adaptor protein that binds to TAK1 (transforming growth factor-beta-activated kinase 1), facilitating its activation. This interaction is essential for downstream signaling in the NF-κB and MAPK pathways, which govern inflammatory responses, immune regulation, cell survival, and apoptosis. TAB1 antibodies are primarily used in research to detect TAB1 expression, localization, and post-translational modifications via techniques like Western blotting, immunoprecipitation, and immunofluorescence.
Dysregulation of TAB1-TAK1 signaling is implicated in diseases such as cancer, autoimmune disorders, and neurodegenerative conditions. For example, TAB1 overexpression has been linked to tumor progression and chemoresistance, while its deficiency may impair inflammatory responses. Researchers also explore TAB1's role in cardiac hypertrophy and ischemia-reperfusion injury, where it modulates stress-responsive pathways. The antibody's specificity and reliability are crucial for elucidating TAB1's dual roles—acting as both a scaffold and a regulatory subunit in TAK1 complexes. Commercial TAB1 antibodies are typically validated in human, mouse, or rat models, aiding translational studies aiming to target this pathway therapeutically.
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