Rabbit Polyclonal KCND3 Antibody

The KCND3 antibody targets the protein encoded by the KCND3 gene, which belongs to the potassium voltage-gated channel subfamily D. This gene encodes the Kv4.3 protein, a key component of voltage-gated A-type potassium channels. These channels regulate the transient outward potassium current (Ito) in excitable tissues, playing a critical role in repolarizing cardiac and neuronal action potentials. In the heart, Kv4.3 contributes to phase 1 repolarization, and its dysfunction is linked to arrhythmias like Brugada syndrome. In the nervous system, it modulates neuronal excitability and synaptic plasticity, with implications in neurodegenerative diseases. KCND3 antibodies are widely used in research to study channel expression, localization, and functional alterations in disease models. They are applied in techniques like Western blotting, immunohistochemistry, and immunofluorescence to detect Kv4.3 in tissues or cultured cells. Commercially available KCND3 antibodies are typically raised in rabbits or mice, with validation via knockout controls or peptide blocking to ensure specificity. Researchers also use these antibodies to explore mutations in KCND3 associated with neurological disorders, such as spinocerebellar ataxia, or cardiac pathologies. Proper validation is essential due to potential cross-reactivity with related potassium channel subunits.