| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | GK; GLK; HK4; HHF3; HKIV; HXKP; LGLK; MODY2; FGQTL3 |
| Entrez GeneID | 2645; |
| WB Predicted band size | 52kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Fusion protein corresponding to a region derived from internal residues of human glucokinase (hexokinase 4) |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于GCK(Glucokinase，葡萄糖激酶)抗体的虚构参考文献示例，格式为文献名称、作者及摘要概括：
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1. **"Autoantibodies against Glucokinase in Type 1 Diabetes: Diagnostic and Pathogenic Implications"**
*作者：Smith A, et al. (2020)*
**摘要**：研究探讨了GCK自身抗体在1型糖尿病中的表达及其诊断价值。通过对比患者与健康人群血清，发现GCK抗体在早期糖尿病中特异性较高，可能参与β细胞功能损伤的免疫机制。
2. **"GCK Antibody-Based Detection of Hepatic Glucokinase Dysregulation in Metabolic Disorders"**
*作者：Zhang L, et al. (2018)*
**摘要**：开发了一种高灵敏度的GCK单克隆抗体检测方法，用于评估非酒精性脂肪肝患者肝组织中GCK蛋白表达水平，发现其表达降低与胰岛素抵抗显著相关。
3. **"Novel GCK Antibodies Reveal Tissue-Specific Isoforms in Pancreatic and Neuroendocrine Tumors"**
*作者：Fernández R, et al. (2021)*
**摘要**：利用新型GCK抗体鉴定出胰腺癌和神经内分泌肿瘤中GCK的异常剪接变体，提示其可能作为肿瘤代谢重编程的生物标志物。
4. **"Maternal GCK Autoantibodies and Gestational Diabetes Mellitus Risk"**
*作者：Tanaka K, et al. (2019)*
**摘要**：分析妊娠期糖尿病患者血清，发现GCK自身抗体阳性率升高，可能与妊娠期胰岛β细胞代偿功能受损相关，为妊娠糖尿病的免疫机制提供新视角。
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注：以上文献为示例性质，实际研究中需根据具体需求检索真实数据库(如PubMed)。
**Background of GCK Antibody**
Glucokinase (GCK), a key enzyme in glucose metabolism, catalyzes the phosphorylation of glucose to glucose-6-phosphate, a critical step in glycolysis. It acts as a glucose sensor in pancreatic β-cells and hepatocytes, regulating insulin secretion and hepatic glucose uptake. Mutations in the *GCK* gene are linked to monogenic diabetes, such as maturity-onset diabetes of the young type 2 (MODY2), characterized by mild hyperglycemia.
GCK antibodies are immunological tools developed to detect, quantify, or inhibit GCK protein expression in research and diagnostics. They play a pivotal role in studying GCK's functional dynamics, tissue-specific expression, and its interaction with regulatory proteins like GKRP (glucokinase regulatory protein). In autoimmune diabetes, rare cases involve autoantibodies targeting GCK, though their clinical significance remains under investigation.
Research utilizing GCK antibodies has advanced understanding of glucose homeostasis dysregulation in diabetes and metabolic disorders. Additionally, therapeutic strategies targeting GCK activation or inhibition are being explored for diabetes treatment. These antibodies thus serve as essential reagents in both basic science and translational studies, bridging molecular insights with potential clinical applications.
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