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Rabbit Polyclonal ADAMTSL2 Antibody

  • 中文名： ADAMTSL2抗体
  • 别    名： GPHYSD1
货号: IPDX42796
Price： ￥1180
数量：
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesGPHYSD1
Entrez GeneID9719;
WB Predicted band size105kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenFusion protein corresponding to residues near the C terminal of human ADAMTS-like 2
FormulationPurified antibody in PBS with 0.05% sodium azide.

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参考文献

以下是关于ADAMTSL2抗体的3篇代表性文献示例(内容为虚构示例，实际文献需通过数据库检索确认)：

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1. **文献名称**: "ADAMTSL2 mutations and cellular extracellular matrix remodeling in geleophysic dysplasia"

**作者**: Le Goff C, et al.

**摘要**: 该研究通过免疫组化及Western blot分析，利用ADAMTSL2特异性抗体，揭示了ADAMTSL2基因突变导致细胞外基质异常，与geleophysic dysplasia(短肢侏儒症)的病理机制相关，抗体验证了患者成纤维细胞中蛋白表达缺失。

2. **文献名称**: "Characterization of ADAMTSL2 antibody for detecting cardiac fibrosis biomarkers"

**作者**: Smith J, et al.

**摘要**: 研究开发并验证了一种高特异性ADAMTSL2多克隆抗体，用于检测心脏纤维化模型中的蛋白表达水平，证实其与TGF-β信号通路的相互作用，为心血管疾病诊断提供潜在工具。

3. **文献名称**: "ADAMTSL2 regulates TGF-β bioavailability in Marfan syndrome-related pathways"

**作者**: Doyle AJ, et al.

**摘要**: 通过ADAMTSL2抗体进行组织染色及功能实验，发现该蛋白通过调控TGF-β活性参与主动脉壁结构维持，抗体应用揭示了其在马凡综合征小鼠模型中的异常分布。

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如需真实文献，建议通过PubMed或Google Scholar检索关键词“ADAMTSL2 antibody”或结合疾病名称筛选。

背景信息

The ADAMTSL2 (A Disintegrin and Metalloproteinase with Thrombospondin Motifs-like 2) antibody is a tool used to study the ADAMTSL2 protein, a member of the ADAMTS superfamily. Unlike canonical ADAMTS proteases, ADAMTSL2 lacks a catalytic domain and functions as a secreted glycoprotein involved in extracellular matrix (ECM) organization and growth factor regulation. It interacts with fibrillin-1. a key component of microfibrils, and modulates TGF-β signaling, influencing tissue development and homeostasis. Mutations in the ADAMTSL2 gene are linked to genetic disorders such as geleophysic dysplasia and Marfan-like syndromes, characterized by skeletal abnormalities, short stature, and cardiovascular complications. The ADAMTSL2 antibody enables detection and localization of the protein in tissues and cell cultures, aiding research into its role in ECM integrity, fibrillin microfibril assembly, and disease mechanisms. Its application spans immunoblotting, immunohistochemistry, and immunofluorescence, providing insights into how ADAMTSL2 dysfunction contributes to connective tissue pathologies. Studies using this antibody have also explored its potential involvement in fibrosis and metabolic pathways, highlighting its broader relevance in developmental biology and translational medicine.

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