| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/15-1/50 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | ACAD-11 |
| Entrez GeneID | 84129; |
| WB Predicted band size | 87kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Fusion protein corresponding to a region derived from internal residues of human Acyl-CoA dehydrogenase family, member 11 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
+ +
以下是关于ACAD11抗体的3篇文献摘要(基于模拟数据，仅供参考)：
1. **文献名称**：*ACAD11 antibody characterization in mitochondrial fatty acid oxidation studies*
**作者**：Smith J, et al.
**摘要**：本研究开发了一种特异性ACAD11抗体，用于检测人类细胞线粒体中的ACAD11蛋白表达，验证其在脂肪酸氧化代谢通路中的作用，并发现其表达水平与神经退行性疾病相关。
2. **文献名称**：*A novel ACAD11 polyclonal antibody for immunohistochemical analysis*
**作者**：Lee S, et al.
**摘要**：报道了一种新型ACAD11多克隆抗体的制备，成功应用于小鼠组织切片的免疫组化分析，揭示了ACAD11在肝脏和心脏中的高表达模式，提示其器官特异性代谢功能。
3. **文献名称**：*ACAD11 deficiency screening using a validated commercial antibody*
**作者**：Garcia R, et al.
**摘要**：通过商业化的ACAD11抗体(货号：ABX-ACAD11)，建立了ACAD11蛋白缺陷的Western Blot诊断方法，在遗传代谢疾病患者中筛选出罕见的ACAD11突变病例。
注：以上为模拟文献，实际引用时建议通过PubMed/Google Scholar以关键词“ACAD11 antibody”检索最新研究。
The ACAD11 antibody targets acyl-CoA dehydrogenase family member 11 (ACAD11), a mitochondrial enzyme belonging to the acyl-CoA dehydrogenase (ACAD) family. ACADs are critical in lipid metabolism, catalyzing the initial dehydrogenation steps in fatty acid β-oxidation. Unlike other ACADs involved in straight-chain fatty acid oxidation, ACAD11 is associated with branched-chain amino acid metabolism and mitochondrial electron transfer processes, though its precise substrates and metabolic roles remain under investigation. ACAD11 has been implicated in rare genetic disorders linked to mitochondrial dysfunction, neurodegenerative conditions, and cancer, where altered lipid metabolism is a hallmark.
ACAD11 antibodies are essential tools for studying the protein's expression, localization, and function. They are commonly used in techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to detect ACAD11 in tissues or cultured cells. Many commercially available ACAD11 antibodies are raised in rabbits or mice, validated for reactivity with human, mouse, or rat samples. Specificity is confirmed through knockout controls or siRNA-mediated silencing. Researchers employ these antibodies to explore ACAD11's role in metabolic diseases, cancer progression, and mitochondrial disorders. Recent studies also investigate its potential as a biomarker or therapeutic target. Proper validation and optimization remain crucial due to sequence homology among ACAD family members and tissue-specific expression patterns.
×
