Rabbit Polyclonal FZD4 Antibody

FZD4 antibodies target Frizzled-4 (FZD4), a member of the Frizzled receptor family that plays a critical role in the Wnt signaling pathway, particularly the Wnt/β-catenin and planar cell polarity (PCP) pathways. FZD4 is a seven-transmembrane receptor that binds Wnt ligands, initiating downstream signaling cascades essential for embryonic development, tissue homeostasis, and angiogenesis. It is notably involved in vascular development in the retina and inner ear, with mutations linked to familial exudative vitreoretinopathy (FEVR) and Norrie disease. FZD4 antibodies are widely used in research to study receptor expression, localization, and function in both normal and pathological contexts. They enable detection of FZD4 in techniques like Western blotting, immunohistochemistry, and immunofluorescence. Additionally, these antibodies are instrumental in exploring FZD4's role in cancer, where aberrant Wnt signaling often drives tumor progression, and in vascular diseases, where dysregulated angiogenesis is a hallmark. Therapeutic strategies targeting FZD4. including neutralizing antibodies, are under investigation to modulate Wnt signaling in diseases such as colorectal cancer and diabetic retinopathy. Understanding FZD4's structure and interactions with co-receptors like LRP5/6 remains a focus for developing targeted therapies.