| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | p18; INK4C; p18-INK4C |
| WB Predicted band size | 18 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Fusion protein of human CDKN2C |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于MATN4抗体的3篇参考文献示例(注：文献为模拟示例，非真实存在)：
1. **"Matrilin-4 (MATN4) Expression in Tumor Microenvironment and Its Role in Cancer Progression"**
*作者：Huang Y, et al. (2020)*
**摘要**：研究利用MATN4特异性抗体检测其在多种癌症组织中的表达，发现MATN4在肿瘤基质中高表达，并通过调节细胞外基质重塑促进肿瘤侵袭，提示其作为预后标志物的潜力。
2. **"MATN4 Knockout Mice Reveal Its Critical Role in Skeletal Development"**
*作者：Smith J, et al. (2018)*
**摘要**：通过MATN4抗体进行免疫组化分析，发现MATN4缺失导致小鼠软骨发育异常，证明其在胶原纤维组装和骨骼稳态中的关键作用。
3. **"MATN4 Antibody-Based Detection in Autoimmune Disorders"**
*作者：Chen L, et al. (2021)*
**摘要**：研究开发了高特异性MATN4单克隆抗体，用于ELISA和Western blot检测，发现类风湿性关节炎患者血清MATN4水平升高，可能与自身免疫反应相关。
4. **"Proteomic Analysis of MATN4 Interactions Using Immunoprecipitation"**
*作者：Wang Q, et al. (2019)*
**摘要**：利用MATN4抗体进行免疫共沉淀实验，鉴定出MATN4与多种基质蛋白的相互作用网络，揭示其在细胞黏附和信号传导中的复杂功能。
(注：以上文献为基于领域知识的模拟内容，实际引用请以真实文献为准。)
The MATN4 antibody is a research tool designed to detect and study matrilin-4 (MATN4), a member of the matrilin family of extracellular matrix (ECM) proteins. Matrilins are involved in ECM assembly, particularly in cartilage and skeletal tissues, where they mediate interactions between collagen fibrils and other matrix components. MATN4. encoded by the *MATN4* gene, is expressed in various tissues, including cartilage, bone, and developing organs, and is implicated in tissue development, homeostasis, and repair.
MATN4 antibodies are widely used in biomedical research to investigate the protein's role in physiological and pathological processes. They enable the detection of MATN4 expression levels via techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF). Studies utilizing these antibodies have linked MATN4 to diseases such as osteoarthritis, cancer (e.g., breast and colorectal tumors), and cardiovascular disorders, where abnormal ECM remodeling occurs.
These antibodies are typically produced in hosts like rabbits or mice, either as polyclonal or monoclonal forms. Specificity and sensitivity depend on the immunogen design, often targeting unique epitopes within MATN4's von Willebrand factor A (vWFA) or epidermal growth factor (EGF)-like domains. Recombinant MATN4 proteins are frequently used for antibody validation. Researchers also employ MATN4 antibodies to explore interactions with ECM partners (e.g., collagens, proteoglycans) and signaling pathways influencing cell adhesion, proliferation, and differentiation.
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