| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | P16 |
| Entrez GeneID | 1029 |
| clone | 2D9A12 |
| WB Predicted band size | 16.5kDa |
| Host/Isotype | Mouse IgG2b |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat,Rabbit |
| Immunogen | Purified recombinant fragment of P16 expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于IGSF8抗体的示例参考文献(注：文献为虚构示例，仅用于演示格式)：
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1. **文献名称**：*IGSF8 regulates immune synapse formation in T cells through antibody-mediated functional blockade*
**作者**：Smith A, et al. (2018)
**摘要**：本研究开发了一种靶向IGSF8的单克隆抗体，用于阻断其在T细胞免疫突触形成中的作用。实验表明，IGSF8抗体抑制了T细胞与抗原呈递细胞的相互作用，揭示了IGSF8在适应性免疫中的关键调控机制。
2. **文献名称**：*Characterization of IGSF8 as a tumor suppressor and its antibody-based detection in cancer*
**作者**：Yamada T, et al. (2015)
**摘要**：通过生成多克隆IGSF8抗体，研究发现IGSF8在多种癌症中表达下调，其抗体可用于免疫组化检测肿瘤组织样本。功能实验表明，IGSF8缺失促进肿瘤细胞迁移，提示其作为转移抑制因子的潜力。
3. **文献名称**：*IGSF8 antibody reveals its role in viral entry as a potential host factor for SARS-CoV-2*
**作者**：Zhang L, et al. (2020)
**摘要**：利用IGSF8中和抗体，本研究证明IGSF8与新冠病毒刺突蛋白相互作用，可能作为辅助受体参与病毒入侵。抗体阻断显著降低了病毒在细胞模型中的感染效率。
4. **文献名称**：*Development of a high-affinity IGSF8 antibody for therapeutic targeting in autoimmune diseases*
**作者**：Lee J, et al. (2021)
**摘要**：报道了一种人源化IGSF8抗体，通过体外和动物模型验证其抑制B细胞过度活化的效果。该抗体在治疗类风湿性关节炎等自身免疫疾病中显示出临床应用前景。
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如需真实文献，建议通过PubMed或Google Scholar搜索关键词“IGSF8 antibody”或“IGSF8 immunoglobulin superfamily member 8”获取最新研究。
The immunoglobulin superfamily member 8 (IGSF8), also known as PGRL or CD316. is a transmembrane protein characterized by extracellular immunoglobulin-like domains. It is broadly expressed in various tissues, including immune cells, neurons, and endothelial cells. IGSF8 is implicated in cell-cell adhesion, immune regulation, and synaptic signaling. Studies suggest its role in modulating T-cell activation, dendritic cell function, and tumor microenvironment interactions, though its precise biological mechanisms remain incompletely defined.
IGSF8 antibodies are tools developed to detect, quantify, or inhibit the protein in research and clinical contexts. These antibodies are utilized in techniques like immunohistochemistry, flow cytometry, and Western blotting to explore IGSF8's expression patterns in health and disease. Emerging evidence links IGSF8 dysregulation to cancers, autoimmune disorders, and neurological conditions, driving interest in its therapeutic targeting. For example, IGSF8 overexpression in certain tumors correlates with immune evasion, making it a potential checkpoint inhibitor target.
Despite progress, challenges persist, including antibody specificity validation and understanding isoform-specific functions. Recent studies also highlight IGSF8's interaction with other immune regulators, such as PD-L1. suggesting combinatorial therapeutic avenues. Ongoing research aims to clarify its signaling pathways and evaluate antibody-based strategies in preclinical models. Overall, IGSF8 antibodies represent both investigative reagents and promising candidates for translational applications in immunotherapy and disease diagnosis.
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