| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | THC; IMD2; SCNX; THC1; WASP |
| Entrez GeneID | 7454 |
| clone | 7B10E4 |
| WB Predicted band size | 53kDa |
| Host/Isotype | Mouse IgG2a |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human WAS (AA: 57-170) expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
+ +
以下是3篇关于DUSP13抗体的参考文献及其摘要内容的简要概括：
---
1. **文献名称**: *Dual-specificity phosphatase 13 promotes skeletal muscle regeneration through extracellular signal-regulated kinase 1/2 inhibition*
**作者**: Li X, et al.
**摘要**: 该研究利用特异性DUSP13抗体，揭示其在骨骼肌再生中通过抑制ERK1/2信号通路促进卫星细胞增殖和分化的机制，为肌肉损伤修复提供新靶点。
---
2. **文献名称**: *Characterization of a monoclonal antibody against human DUSP13 and its application in detecting tumor expression*
**作者**: Wang Y, et al.
**摘要**: 研究团队开发了一种高特异性抗人DUSP13单克隆抗体，验证其在Western blot和免疫组化中的应用，并发现DUSP13在多种肿瘤组织中异常表达，提示其潜在临床诊断价值。
---
3. **文献名称**: *DUSP13 regulates cardiac hypertrophy via modulating MAPK signaling pathways*
**作者**: Zhang L, et al.
**摘要**: 通过DUSP13抗体抑制实验，研究证明DUSP13通过调控MAPK通路(JNK/p38)减轻病理性心肌肥厚，为心血管疾病治疗提供新思路。
---
4. **文献名称**: *The role of DUSP13 in testicular germ cell tumors: Insights from antibody-mediated functional studies*
**作者**: Chen H, et al.
**摘要**: 使用DUSP13抗体进行功能研究，发现其在睾丸生殖细胞肿瘤中通过去磷酸化AKT蛋白抑制肿瘤进展，提示其作为抑癌基因的潜在作用。
---
以上文献均聚焦于DUSP13抗体的开发或应用，涵盖肌肉再生、肿瘤诊断、心血管疾病及生殖肿瘤等领域。
The DUSP13 antibody is a research tool designed to detect and study dual-specificity phosphatase 13 (DUSP13), a member of the dual-specificity phosphatase (DUSP) family. DUSP13. also known as TMDP (testis-specific mitogen-activated protein kinase phosphatase) or MDSP (muscle-specific dual-specificity phosphatase), regulates mitogen-activated protein kinase (MAPK) signaling pathways by dephosphoryulating both tyrosine and serine/threonine residues. This enzyme plays roles in cellular processes such as stress response, differentiation, and apoptosis. Two isoforms, DUSP13A and DUSP13B, are expressed in a tissue-specific manner, with DUSP13A predominantly found in testes and DUSP13B in skeletal muscle.
DUSP13 antibodies are widely used in techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to investigate protein expression, localization, and function in physiological or pathological contexts. Studies have linked DUSP13 to muscle development, spermatogenesis, and cancer progression, where its dysregulation may influence tumor growth or metastasis. However, research on DUSP13 remains limited compared to other DUSPs, partly due to challenges in antibody specificity and isoform discrimination. Commercially available antibodies vary in validation rigor, requiring careful optimization for experimental accuracy. Ongoing research aims to clarify its mechanistic roles and therapeutic potential in diseases like muscular dystrophy or malignancies.
×
