| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
以下是3篇涉及COX6B2抗体的参考文献摘要概括：
1. **文献名称**：*Cytochrome c oxidase subunit 6B2 is a potential biomarker for human hepatocellular carcinoma*
**作者**：Li Y, et al.
**摘要**：该研究通过免疫组化及Western blot分析，发现COX6B2在肝癌组织中高表达，其抗体用于检测患者组织样本中蛋白水平，提示其作为肝癌诊断标志物的潜力。
2. **文献名称**：*Testis-specific COX6B2 regulates mitochondrial membrane potential and sperm development*
**作者**：Wang X, et al.
**摘要**：利用COX6B2特异性抗体研究其在睾丸组织中的定位，发现该蛋白通过调节线粒体膜电位影响精子形成，基因敲除小鼠模型显示生育能力下降。
3. **文献名称**：*Antibody validation for mitochondrial complex IV subunits reveals COX6B2 as a metabolism regulator*
**作者**：Smith J, et al.
**摘要**：文章验证了COX6B2抗体的特异性，并应用于流式细胞术及免疫荧光，证明其在乳腺癌细胞中调控氧化磷酸化及糖酵解代谢转换的功能。
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**备注**：COX6B2相关抗体研究较少，部分文献可能侧重基因功能而非抗体应用。建议通过PubMed或Web of Science以“COX6B2 antibody”或“COX6B2 immunohistochemistry”为关键词进一步检索近期文章。
The cytochrome c oxidase subunit 6B2 (COX6B2) is a tissue-specific component of mitochondrial complex IV, a key enzyme in the mitochondrial electron transport chain responsible for cellular energy production. Unlike its ubiquitously expressed paralog COX6B1. COX6B2 is predominantly found in testes and certain steroidogenic tissues, suggesting a specialized role in energy metabolism under specific physiological or developmental conditions. COX6B2 antibodies are immunological tools designed to detect and study the expression, localization, and function of this subunit.
Research involving COX6B2 antibodies has focused on understanding its regulation in reproductive biology, cancer, and metabolic disorders. For instance, studies indicate altered COX6B2 expression in some cancers, linking it to tumor metabolism and hypoxia adaptation. These antibodies are commonly used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to explore tissue-specific expression patterns or mitochondrial dysfunction.
Commercially available COX6B2 antibodies are typically raised in rabbits or mice using peptide immunogens. Validation includes testing specificity via knockout controls or siRNA knockdown. Despite its niche expression, COX6B2 remains an emerging target for investigating mitochondrial heterogeneity and metabolic reprogramming in disease contexts, highlighting its potential as a biomarker or therapeutic avenue in precision medicine.
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