| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | AII; AVP; FCU; MWS; FCAS; CIAS1; NALP3; C1orf7; CLR1.1; PYPAF1; AGTAVPRL |
| Entrez GeneID | 114548; |
| WB Predicted band size | 118kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Fusion protein corresponding to a region derived from internal residues of human NLR family, pyrin domain containing 3 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于NLRP3抗体的3篇参考文献示例(注：部分文献信息为虚构示例，实际引用时请核实原文准确性)：
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1. **文献名称**：*A human monoclonal antibody targeting NLRP3 suppresses inflammasome activity and attenuates inflammatory diseases*
**作者**：Zhang L, et al.
**摘要**：本研究开发了一种靶向NLRP3的人源单克隆抗体，通过体外和体内实验证明其能够特异性抑制NLRP3炎症小体的组装与活化，显著减轻小鼠模型中类风湿性关节炎和痛风的炎症反应，为治疗NLRP3相关疾病提供新策略。
2. **文献名称**：*NLRP3 antibody-based detection of inflammasome activation in Alzheimer’s disease models*
**作者**：Venegas C, et al.
**摘要**：通过使用特异性NLRP3抗体进行免疫组化和Western blot分析，研究发现阿尔茨海默病小鼠脑组织中NLRP3炎症小体活化水平升高，且与β-淀粉样蛋白沉积相关，提示NLRP3可能是神经炎症的潜在治疗靶点。
3. **文献名称**：*Therapeutic inhibition of NLRP3 by monoclonal antibody improves metabolic dysfunction in obesity*
**作者**：Lee S, et al.
**摘要**：该研究利用抗NLRP3单克隆抗体阻断肥胖小鼠模型中的炎症信号通路，结果显示其可显著减少脂肪组织炎症、改善胰岛素抵抗，证实靶向NLRP3的抗体疗法对代谢综合征具有治疗潜力。
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建议通过PubMed或Google Scholar搜索实际文献时使用关键词如“NLRP3 antibody therapeutic”、“NLRP3 inflammasome detection”等获取最新研究。
NLRP3 antibodies are tools used to study the NLRP3 (NOD-like receptor protein 3) inflammasome, a key component of the innate immune system. NLRP3 is a cytoplasmic sensor that detects pathogen-associated molecular patterns (PAMPs) and damage-associated molecular patterns (DAMPs), triggering inflammation. Upon activation, NLRP3 oligomerizes with ASC (apoptosis-associated speck-like protein) and procaspase-1 to form the inflammasome complex, which cleaves pro-inflammatory cytokines like IL-1β and IL-18. promoting pyroptosis and systemic inflammation. Dysregulated NLRP3 activity is linked to autoimmune diseases (e.g., rheumatoid arthritis, gout), neurodegenerative disorders (e.g., Alzheimer’s), and metabolic syndromes (e.g., type 2 diabetes).
NLRP3 antibodies are essential for detecting NLRP3 expression, localization, and activation in research. They help elucidate mechanisms of inflammasome assembly, regulation, and its role in disease pathogenesis. Therapeutic NLRP3-targeting antibodies or inhibitors are under investigation to block excessive inflammation, with some in clinical trials for conditions like cryopyrin-associated periodic syndromes (CAPS). However, challenges remain in balancing immune suppression and host defense. These antibodies also aid in biomarker discovery and evaluating drug efficacy, making them critical for both basic research and translational medicine.
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