Rabbit Polyclonal MCPH1 Antibody

The MCPH1 antibody is a crucial tool for studying the Microcephalin (MCPH1) protein, encoded by the *MCPH1* gene, which plays a vital role in brain development and neurogenesis. Mutations in *MCPH1* are linked to autosomal recessive primary microcephaly, a neurodevelopmental disorder characterized by reduced brain size and intellectual disability. The protein regulates mitotic progression, DNA damage response, and chromosome condensation, interacting with key molecules like BRCA1 and CHK2 to maintain genomic stability. MCPH1 antibodies are widely used in techniques such as Western blotting, immunofluorescence, and immunohistochemistry to detect protein expression, localization, and dynamics in cellular and tissue contexts. These antibodies help elucidate MCPH1's roles in neurogenesis, cell cycle checkpoints, and its potential involvement in cancer, where dysregulation has been observed in breast and ovarian tumors. Researchers also employ MCPH1 antibodies to investigate species-specific conservation (human, mouse, rat) and validate gene-editing models. Commercial antibodies are typically developed as monoclonal or polyclonal variants, with specificity confirmed through knockout/knockdown validation. Their applications span neurobiology, oncology, and genetics, aiding in mechanistic studies of microcephaly-related pathways and broader genomic stability processes. Proper validation remains critical due to potential cross-reactivity with homologous proteins.