| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | DKFZp686M05248; MGC102856; MGC42116; p53-inducible ribonucleotide reductase small subunit 2 homolog; p53-inducible ribonucleotide reductase small subunit 2-like protein |
| Entrez GeneID | 50484; |
| WB Predicted band size | 40kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | Synthesized peptide derived from Internal of human RRM2B. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于RRM2B抗体的3篇参考文献示例(注：文献信息为模拟示例，非真实存在)：
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1. **文献名称**：*RRM2B expression correlates with mitochondrial dysfunction in colorectal cancer*
**作者**：Smith A, et al.
**摘要**：本研究通过免疫组化(使用RRM2B抗体)和Western blot分析结直肠癌组织中RRM2B蛋白的表达水平，发现其表达缺失与线粒体DNA损伤和患者预后不良显著相关，提示RRM2B在肿瘤代谢中的关键作用。
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2. **文献名称**：*RRM2B deficiency induces chemoresistance via impaired DNA repair in breast cancer*
**作者**：Chen L, et al.
**摘要**：文章利用RRM2B特异性抗体进行蛋白印迹和免疫荧光实验，证明RRM2B缺失导致乳腺癌细胞对化疗药物耐药，机制与DNA修复通路(如ATM/ATR信号)的异常激活有关。
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3. **文献名称**：*A novel RRM2B mutation identified in patients with mitochondrial encephalomyopathy*
**作者**：Wang Y, et al.
**摘要**：研究者通过Western blot(使用抗RRM2B抗体)和基因测序，在遗传性线粒体脑肌病患者中鉴定出新型RRM2B突变，证实该突变导致蛋白功能丧失，进而引发线粒体呼吸链复合体缺陷。
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**说明**：以上文献为模拟内容，实际研究中建议通过PubMed、Google Scholar等平台检索关键词(如“RRM2B antibody application”“RRM2B immunohistochemistry”)获取真实文献。若需具体论文，可提供更详细的研究方向或应用场景。
The RRM2B (Ribonucleotide Reductase Regulatory TP53 Inducer Subunit M2B) antibody is a tool used to detect and study the RRM2B protein, a critical enzyme involved in DNA synthesis and repair. RRM2B, also known as p53R2. is a subunit of the ribonucleotide reductase (RNR) complex, which catalyzes the conversion of ribonucleotides to deoxyribonucleotides—essential precursors for DNA replication and repair. Unlike its homolog RRM2. RRM2B is regulated by the tumor suppressor protein p53 and plays a key role in mitochondrial DNA (mtDNA) maintenance by supplying deoxyribonucleotides to mitochondria under stress conditions.
Research on RRM2B has highlighted its importance in mitochondrial function, genome stability, and cellular responses to oxidative stress or DNA damage. Mutations in the RRM2B gene are linked to severe mitochondrial disorders, such as mitochondrial encephalomyopathy, chronic progressive external ophthalmoplegia (CPEO), and Kearns-Sayre syndrome (KSS), characterized by mtDNA depletion or deletions. The RRM2B antibody is widely used in Western blotting, immunohistochemistry, and immunofluorescence to investigate protein expression patterns, subcellular localization, and its role in diseases. It also aids in studying cancer biology, as RRM2B dysregulation has been implicated in tumorigenesis, chemoresistance, and response to radiation therapy. This antibody serves as a vital reagent for elucidating RRM2B's molecular mechanisms and its potential as a therapeutic target.
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