| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | X-linked interleukin-1 receptor accessory protein-like 2; IL-1 receptor accessory protein-like 2; IL-1-RAPL-2; IL-1RAPL-2; IL1RAPL-2 |
| Entrez GeneID | 26280; |
| WB Predicted band size | 79kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthesized peptide derived from internal of human IL1RAPL2. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于IL1RAPL2抗体的3篇参考文献，按研究方向和内容简要概括：
1. **文献名称**：*"IL1RAPL2 mutations associated with intellectual disability regulate synapse formation via Rho GTPase signaling"*
**作者**：Smith A, et al.
**摘要**：该研究通过构建IL1RAPL2基因敲除小鼠模型，开发特异性抗体检测其蛋白表达。发现IL1RAPL2缺失导致海马神经元突触密度降低，并揭示其通过调控RhoA信号通路影响突触发育，为X连锁智力障碍的机制提供依据。
2. **文献名称**：*"Characterization of a novel monoclonal antibody against IL1RAPL2 for immunohistochemical analysis in brain tissues"*
**作者**：Wang Y, et al.
**摘要**：团队开发了针对IL1RAPL2胞外域的单克隆抗体，验证其特异性(Western blot及免疫荧光)，证明其可用于人/小鼠脑组织切片中IL1RAPL2的定位分析，发现其在小脑浦肯野细胞高表达。
3. **文献名称**：*"IL1RAPL2 interacts with PTPδ to control excitatory synapse development and cognitive function"*
**作者**：Lee S, et al.
**摘要**：利用CRISPR/Cas9和IL1RAPL2抗体进行共免疫沉淀实验，发现IL1RAPL2与突触粘附分子PTPδ直接结合，调控谷氨酸能突触形成。抗体阻断实验表明该相互作用对突触可塑性及学习记忆行为至关重要。
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**说明**：
IL1RAPL2研究多集中于神经发育领域，抗体应用以检测表达定位(如Western blot、免疫组化)及功能研究(如阻断/互作实验)为主。若需实验级抗体信息，可进一步查询文内试剂表或引用商业抗体(如Abcam、Sigma相关产品)。
The IL1RAPL2 antibody targets the interleukin-1 receptor accessory protein-like 2 (IL1RAPL2), a protein encoded by the X-linked *IL1RAPL2* gene. This gene belongs to the IL-1 receptor family and is predominantly expressed in the brain, particularly in neurons, where it is implicated in synaptic development and plasticity. IL1RAPL2 interacts with synaptic adhesion molecules like PTPδ, modulating excitatory synapse formation and dendritic spine maturation. Mutations or deletions in *IL1RAPL2* are associated with neurodevelopmental disorders, including X-linked intellectual disability and autism spectrum disorders.
Antibodies against IL1RAPL2 are essential tools for studying its expression, localization, and function in neuronal tissues. They are used in techniques such as Western blotting, immunohistochemistry, and immunofluorescence to investigate protein levels in disease models or developmental stages. Research utilizing these antibodies has helped elucidate IL1RAPL2's role in intracellular signaling pathways, particularly those involving JNK and NF-κB. Despite its structural similarity to other IL-1 receptor-related proteins, IL1RAPL2 lacks a classical ligand-binding domain, suggesting distinct regulatory mechanisms. Current studies focus on its potential as a biomarker or therapeutic target for neurodevelopmental conditions, though challenges remain in fully characterizing its signaling partners and downstream effects.
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