Rabbit Polyclonal VRK3 Antibody

The VRK3 (vaccinia-related kinase 3) antibody is a tool used to study the VRK3 protein, a member of the VRK serine/threonine kinase family. VRK3. encoded by the *VRK3* gene in humans, shares structural homology with VRK1 and VRK2 but exhibits distinct functional characteristics. Unlike other VRK family members, VRK3 lacks catalytic kinase activity due to evolutionary mutations in its ATP-binding domain. It plays roles in cellular processes such as cell cycle regulation, stress response, and neural development, often acting as a pseudokinase to modulate signaling pathways through protein interactions. Studies suggest VRK3 interacts with phosphatase VHR (VH1-related) to regulate MAPK signaling and may influence chromatin dynamics via associations with HDACs (histone deacetylases). Its expression is prominent in the brain, and dysregulation has been linked to neurological disorders and cancers, including glioblastoma. The VRK3 antibody enables detection and localization of VRK3 in experimental models (e.g., Western blot, immunohistochemistry), aiding research into its biological mechanisms and disease associations. Commercial VRK3 antibodies are typically validated for specificity, often targeting epitopes within its unique N-terminal or C-terminal regions. Ongoing studies focus on clarifying its pseudokinase-driven regulatory functions and potential therapeutic relevance.