Rabbit Polyclonal STK17B Antibody

The STK17B (serine/threonine kinase 17B) antibody is a tool used to study the STK17B protein, a member of the death-associated protein kinase (DAPK)-related apoptosis-inducing kinase family. STK17B plays roles in regulating apoptosis, autophagy, and cellular responses to oxidative stress. It is implicated in diseases like cancer, where its expression is often dysregulated. For instance, STK17B overexpression has been linked to tumor suppression in certain contexts, while reduced levels are associated with chemoresistance. The antibody enables detection and quantification of STK17B in various applications, including Western blotting, immunohistochemistry, and immunofluorescence. Researchers use it to investigate STK17B’s involvement in signaling pathways, its interaction partners, and its potential as a biomarker or therapeutic target. Most antibodies target specific epitopes within its kinase domain or C-terminal regulatory region. Validation typically includes testing in knockout cell lines to confirm specificity. Host species (e.g., rabbit, mouse) and reactivity (human, mouse, rat) vary by product. Understanding STK17B’s role via such antibodies contributes to unraveling its dual pro-survival and pro-death functions in health and disease.