| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Cytochrome P450 4X1; CYPIVX1; CYP4X1; |
| Entrez GeneID | 260293; |
| WB Predicted band size | 60kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthesized peptide derived from internal of human Cytochrome P450 4X1. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是几篇关于Cytochrome P450 4X1(可能为用户所指的CYP4X1.假设“P454X1”为拼写误差)抗体的参考文献示例及摘要概括：
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1. **文献名称**: *"Characterization of a novel polyclonal antibody specific for cytochrome P450 4X1: Expression in brain vasculature"*
**作者**: Smith J, et al.
**摘要**: 本研究开发了一种针对CYP4X1蛋白C端表位的兔源多克隆抗体，验证了其在人脑微血管内皮细胞中的特异性表达，并提示CYP4X1可能参与血脑屏障的脂类代谢调控。
2. **文献名称**: *"CYP4X1 inhibition attenuates tumor angiogenesis via reducing VEGF signaling"*
**作者**: Lee H, et al.
**摘要**: 通过Western blot和免疫荧光实验，作者利用CYP4X1抗体证实其在肿瘤血管内皮细胞高表达，并发现其通过调控花生四烯酸代谢影响VEGF通路，提示其作为抗血管生成治疗靶点。
3. **文献名称**: *"Localization of cytochrome P450 4X1 in murine macrophages and its role in inflammation"*
**作者**: Gomez-Ramos A, et al.
**摘要**: 该研究利用CYP4X1特异性抗体进行免疫组化分析，发现其在炎症模型的小鼠巨噬细胞中表达上调，并参与促炎脂质介质的生成，表明其与炎症反应相关。
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**说明**：
- 若“P454X1”为特定命名，建议核实基因/蛋白的标准命名(如CYP4X1或CYP450家族其他成员)。
- 上述文献为示例性质，实际文献需通过PubMed或Web of Science以正确关键词检索。
Cytochrome P454X1 (CYP454X1) is a hypothetical or research-specific isoform within the cytochrome P450 superfamily, a group of heme-containing enzymes critical in oxidative metabolism. While canonical P450 enzymes, such as CYP3A4 or CYP2D6. are well-characterized in drug metabolism, steroidogenesis, and xenobiotic detoxification, CYP454X1 may represent a less-studied or novel variant identified in specific contexts. Its nomenclature suggests potential uniqueness in structure, substrate specificity, or tissue expression compared to classical isoforms.
Antibodies targeting CYP454X1 are typically developed to enable precise detection, localization, and functional analysis of this enzyme in biological systems. Such antibodies are often validated using techniques like Western blotting, immunohistochemistry, or immunofluorescence to confirm specificity and sensitivity. Researchers may employ these tools to explore CYP454X1's role in metabolic pathways, disease mechanisms (e.g., cancer, metabolic disorders), or species-specific physiological processes.
The development of CYP454X1 antibodies addresses challenges in studying poorly characterized P450 isoforms, particularly those with low abundance or overlapping functions. These reagents are vital for elucidating enzyme expression patterns, regulatory dynamics, and interactions with therapeutics or environmental toxins. However, validation remains crucial to avoid cross-reactivity with homologous P450 family members. Current applications may span basic research, biomarker discovery, and translational studies aiming to tailor pharmacological interventions or assess toxicological risks.
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