| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Cytochrome P450 4F11; CYPIVF11; CYP4F11; |
| Entrez GeneID | 57834; |
| WB Predicted band size | 60kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthesized peptide derived from internal of human Cytochrome P450 4F11. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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您提到的“Cytochrome P454F11”可能是一个名称拼写错误或虚构的蛋白，目前没有相关文献记录。以下是基于类似名称(如CYP4F11)的假设性文献示例，供参考：
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1. **标题**: "Characterization of a novel CYP4F11 polyclonal antibody in human liver microsomes"
**作者**: Smith J, et al.
**摘要**: 研究开发了针对CYP4F11的多克隆抗体，验证了其在人肝微粒体中的特异性，并探讨了该酶在脂肪酸羟基化中的作用。
2. **标题**: "Role of CYP4F11 in arachidonic acid metabolism: Insights from antibody-based inhibition studies"
**作者**: Lee H, et al.
**摘要**: 利用CYP4F11单克隆抗体阻断酶活性，发现其参与花生四烯酸代谢，可能影响炎症相关信号通路。
3. **标题**: "Tissue-specific expression profiling of CYP4F11 using immunohistochemistry"
**作者**: Garcia R, et al.
**摘要**: 通过免疫组化分析，揭示了CYP4F11在肝脏、肾脏中的差异表达，提示其器官特异性代谢功能。
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**备注**：若目标蛋白名称有误，建议核对标准命名(如CYP4F11、CYP3A4等)或提供更多背景信息，以便提供更准确的文献支持。
Cytochrome P450 4F11 (CYP4F11) is a member of the cytochrome P450 superfamily, a group of heme-containing enzymes critical in metabolizing endogenous and exogenous compounds, including fatty acids, eicosanoids, and drugs. The CYP4F subfamily, including CYP4F11. is primarily involved in hydroxylation and oxidation reactions, particularly in the metabolism of long-chain fatty acids, leukotrienes, and vitamin K. CYP4F11 is expressed in human tissues such as the liver, kidney, and brain, where it contributes to lipid homeostasis and detoxification processes. Dysregulation of CYP4F11 has been implicated in metabolic disorders, drug interactions, and certain cancers, highlighting its physiological and pathological relevance.
Antibodies targeting CYP4F11 are essential tools for studying its expression, localization, and function in biological systems. These antibodies enable detection via techniques like Western blotting, immunohistochemistry, and immunofluorescence. Researchers use them to explore tissue-specific expression patterns, regulatory mechanisms (e.g., induction by xenobiotics), and associations with diseases such as hepatic fibrosis or neurodegenerative conditions. Commercially available CYP4F11 antibodies are typically raised in rabbits or mice, often validated for specificity against recombinant proteins or peptide epitopes. However, challenges like cross-reactivity with homologous CYP4F isoforms require careful validation. Studying CYP4F11 with such antibodies advances understanding of its role in lipid metabolism and potential therapeutic targeting.
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