| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Cytochrome P450; family 3; subfamily A; polypeptide 7; CYP3A7 |
| Entrez GeneID | 1551; |
| WB Predicted band size | 50kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthesized peptide derived from internal of human Cytochrome P450 3A7. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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您提到的“Cytochrome P453A7”可能是名称拼写或格式错误，目前科学文献中未见该名称的明确记录。推测您可能指的是细胞色素P450家族中的某个亚型(如**CYP3A7**，一种在胎儿肝脏中高表达的酶)。以下是基于**CYP3A7抗体**的相关文献示例，供参考：
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1. **文献名称**：*Developmental expression of CYP3A7 in human liver*
**作者**：Hakkola J, et al.
**摘要**：研究CYP3A7在胎儿肝脏中的特异性表达，利用特异性抗体进行免疫组化分析，揭示其在胎儿发育阶段的代谢功能。
2. **文献名称**：*Monoclonal antibodies directed to CYP3A7: Tools for enzyme quantification*
**作者**：Yang D, et al.
**摘要**：开发针对CYP3A7的单克隆抗体，验证其特异性及在Western blot和ELISA中的定量应用，支持胎儿药物代谢研究。
3. **文献名称**：*CYP3A7 polymorphism and its impact on drug metabolism*
**作者**：Sim SC, et al.
**摘要**：分析CYP3A7基因多态性对药物代谢的影响，使用抗体检测蛋白表达水平，探讨个体化用药的潜在意义。
4. **文献名称**：*CYP3A7 in pediatric liver diseases: Expression profiling using immunohistochemistry*
**作者**：Tateishi T, et al.
**摘要**：通过抗体介导的免疫组化技术，评估CYP3A7在儿童肝脏疾病中的异常表达，提示其病理生理学作用。
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**建议**：若您的研究对象确为“P453A7”，请核实名称的正确性(如是否为CYP3A4、CYP2A7等)，或提供更多背景信息以便进一步检索。
Cytochrome P450 3A7 (CYP3A7) is a member of the cytochrome P450 enzyme family, primarily expressed in fetal and neonatal liver tissues. It plays a critical role in the metabolism of endogenous compounds, including steroid hormones, and exogenous substances such as drugs and toxins. Unlike its closely related isoform CYP3A4. which dominates in adults, CYP3A7 is active during early development, contributing to detoxification and hormonal regulation in utero and infancy. Its expression declines postnatally, though residual activity may persist in certain pathological conditions.
Antibodies targeting CYP3A7 are essential tools for studying its expression, localization, and functional roles in developmental biology, pharmacology, and disease research. These antibodies enable detection via techniques like Western blotting, immunohistochemistry, and ELISA, aiding investigations into fetal drug exposure, metabolic disorders, or pediatric liver diseases. Specificity is crucial, as cross-reactivity with other CYP3A isoforms (e.g., CYP3A4. CYP3A5) must be minimized to ensure accurate experimental outcomes. Research utilizing CYP3A7 antibodies has also explored its potential involvement in cancer, particularly malignancies with fetal-like metabolic signatures. However, challenges remain in fully elucidating its regulatory mechanisms and interactions, underscoring the continued need for reliable immunoreagents in both basic and clinical studies.
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