Rabbit Polyclonal CYP4V2 Antibody

The CYP4V2 antibody is a research tool targeting the CYP4V2 protein, a member of the cytochrome P450 enzyme family involved in lipid metabolism. CYP4V2. encoded by the *CYP4V2* gene on chromosome 4q35. plays a role in fatty acid oxidation and is highly expressed in the retina, liver, and other tissues. Mutations in *CYP4V2* are linked to Bietti crystalline dystrophy (BCD), a rare autosomal recessive retinal disorder characterized by lipid crystal deposits in the retina, progressive vision loss, and choroidal atrophy. The CYP4V2 antibody is primarily used in biomedical research to study protein expression, localization, and function in cellular and animal models. It aids in investigating disease mechanisms underlying BCD, particularly how *CYP4V2* mutations disrupt lipid homeostasis and contribute to retinal degeneration. Commercially available as polyclonal or monoclonal antibodies, it is validated for techniques like Western blotting, immunohistochemistry, and immunofluorescence. Recent studies also explore CYP4V2's potential roles beyond BCD, including in cancer and metabolic syndromes, given its enzymatic activity in processing bioactive lipids. However, challenges remain in standardizing antibody specificity across experimental conditions. Ongoing research aims to refine detection methods and clarify CYP4V2's broader physiological and pathological significance.