Rabbit Polyclonal CP26C Antibody

The CP26C antibody is a monoclonal antibody primarily used in research to detect specific isoforms of α-tubulin, a key component of microtubules in eukaryotic cells. Developed as a tool for studying cytoskeletal dynamics, it targets post-translationally modified forms of α-tubulin, such as acetylated or detyrosinated variants, which are associated with stabilized microtubule structures. This antibody has been widely employed in cell biology to investigate processes like mitosis, intracellular transport, and cell motility, where microtubule stability and reorganization play critical roles. Its specificity for modified α-tubulin makes it valuable for distinguishing between dynamic and static microtubule populations in immunofluorescence, Western blotting, and immunoprecipitation assays. CP26C has contributed to studies linking microtubule dysregulation to diseases, including cancer (e.g., chemoresistance mechanisms) and neurodegenerative disorders. While its exact immunogen and host species (commonly mouse or rabbit) may vary depending on commercial sources, CP26C remains a staple reagent for probing microtubule-related cellular mechanisms. Researchers often validate its performance using cell lines or tissues with known tubulin modification states to ensure experimental reliability.