Rabbit Polyclonal BCL7A Antibody

The BCL7A antibody is a tool used to detect the B-cell lymphoma 7A (BCL7A) protein, a member of the BCL7 family implicated in chromatin remodeling and transcriptional regulation. BCL7A is part of the SWI/SNF (BAF) chromatin-remodeling complex, which modulates gene expression by altering nucleosome structure. While its exact biological role remains under investigation, BCL7A is linked to tumor suppression, particularly in B-cell malignancies. Dysregulation or mutations in BCL7A have been observed in lymphoid cancers, including diffuse large B-cell lymphoma (DLBCL) and Burkitt lymphoma, often co-occurring with alterations in MYC or BCL6. Antibodies targeting BCL7A are employed in research to study its expression patterns, interaction partners, and involvement in oncogenesis. They are critical for techniques like Western blotting, immunohistochemistry, and immunofluorescence, aiding in understanding BCL7A’s role in cellular processes and disease. Additionally, BCL7A antibodies may help identify diagnostic or prognostic biomarkers, given its potential association with clinical outcomes in hematologic malignancies. Further studies aim to clarify its mechanistic contributions to chromatin dynamics and cancer pathways, positioning BCL7A as a molecule of interest in both basic and translational oncology research.