Rabbit Polyclonal ZAR1 Antibody

The ZAR1 antibody is linked to the study of the zygotic arrest 1 (ZAR1) protein, a conserved ooplasmic factor critical in early embryonic development. Initially identified in mammals, ZAR1 is essential for oocyte-to-embryo transition, regulating maternal mRNA stability and translation. Its role in fertility and embryogenesis has made it a focus in reproductive biology. Antibodies targeting ZAR1 have been developed primarily for research to elucidate its molecular mechanisms and interactions. In immunology, ZAR1 gained attention due to its unexpected connection to autoimmunity. Recent studies revealed that ZAR1 forms a plant-like "resistosome" complex in humans, triggering inflammatory cell death (pyroptosis) upon pathogen detection. This discovery linked ZAR1 to NLR (nucleotide-binding leucine-rich repeat) protein networks, bridging developmental biology and innate immunity. ZAR1 antibodies now serve dual purposes: probing embryogenic functions and investigating its role in immune responses. Their applications span infertility research, autoimmune disease models (e.g., rheumatoid arthritis), and host-pathogen interaction studies. However, therapeutic potential remains exploratory, with most work confined to preclinical studies. Challenges include understanding tissue-specific ZAR1 isoforms and reconciling its developmental versus immunological roles. These antibodies continue to be vital tools in decoding ZAR1's multifaceted biology across evolutionarily diverse processes.