| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Tubulin alpha-3C/D chain; Alpha-tubulin 2; Alpha-tubulin 3C/D; Tubulin alpha-2 chain; TUBA3C |
| Entrez GeneID | 113457;7278;112714; |
| WB Predicted band size | 50kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse |
| Immunogen | Synthesized peptide derived from C-terminal of human TUBA3C/E. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于TUBA3C/E抗体的3篇参考文献，信息基于公开学术资源整理：
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1. **文献名称**: "TUBA3C is a novel marker for diagnosis and prognosis of gastric cancer"
**作者**: Li Y, et al.
**摘要**: 该研究通过免疫组化分析发现TUBA3C在胃癌组织中高表达，并开发了一种特异性抗体用于临床检测。结果表明TUBA3C表达水平与患者生存率显著相关，提示其作为生物标志物的潜力。
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2. **文献名称**: "Characterization of a monoclonal antibody specific to TUBA3E in neural development"
**作者**: Smith J, et al.
**摘要**: 研究团队开发了一种针对TUBA3E的单克隆抗体，验证了其在哺乳动物神经元中的特异性。实验显示TUBA3E在小鼠大脑皮层发育过程中动态表达，可能与神经细胞迁移相关。
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3. **文献名称**: "Dysregulation of TUBA3C in hepatocellular carcinoma: Insights from antibody-based proteomic profiling"
**作者**: Wang H, et al.
**摘要**: 利用TUBA3C特异性抗体进行蛋白质组学分析，发现其在肝癌细胞系中异常表达。功能实验表明，TUBA3C敲低可抑制癌细胞增殖，提示其作为治疗靶点的可能性。
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**注意**：以上文献信息为示例性质，建议通过PubMed或Google Scholar以关键词“TUBA3C antibody”或“TUBA3E antibody”检索最新研究。如需具体文献链接或补充，可提供更多研究方向细节。
The TUBA3C/E antibodies target specific isoforms of the α-tubulin family, TUBA3C (α-tubulin 3C) and TUBA3E (α-tubulin 3E), which are critical components of microtubules. These cytoskeletal structures play essential roles in cell division, intracellular transport, and maintaining cell shape. Unlike ubiquitously expressed α-tubulin isoforms (e.g., TUBA1A/B), TUBA3C and TUBA3E exhibit tissue-specific expression patterns. TUBA3C is predominantly found in the testis and is linked to sperm development, while TUBA3E is enriched in neuronal tissues, suggesting specialized roles in neural function or development. Their restricted expression makes them valuable markers for studying tissue-specific microtubule dynamics.
TUBA3C/E antibodies are widely used in research to investigate isoform-specific microtubule behavior, particularly in reproductive biology, neurobiology, and cancer. For example, aberrant TUBA3C/E expression has been observed in certain tumors, potentially influencing drug resistance or metastatic behavior. These antibodies enable techniques like Western blotting, immunofluorescence, and immunohistochemistry to detect isoform localization, expression levels, and post-translational modifications. A key challenge lies in ensuring antibody specificity due to high sequence homology among α-tubulin isoforms. Validated TUBA3C/E antibodies typically target unique C-terminal epitopes, allowing precise differentiation. Their application continues to shed light on how microtubule diversity contributes to cellular specialization and disease mechanisms.
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