| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | TGF-beta-induced apoptosis protein 12; TAIP-12; Protein FAM130A1; Protein FAM130A1; Protein FAM130A1 |
| Entrez GeneID | 81566; |
| WB Predicted band size | 60kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthesized peptide derived from internal of human TAIP-12. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是基于假设的TAIP-12抗体相关文献示例(注意：TAIP-12抗体可能为虚构名称，实际文献需进一步验证)：
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1. **文献名称**: *TAIP-12 Antibody Characterization in Autoimmune Disease Models*
**作者**: Zhang L, et al.
**摘要**: 本研究首次报道了TAIP-12抗体的制备及验证，证明其在免疫印迹(Western blot)和免疫组化中特异性识别TAIP-12蛋白。实验表明，TAIP-12在T细胞中高表达，并在类风湿性关节炎小鼠模型中呈现调控作用。
2. **文献名称**: *Role of TAIP-12 in T-Cell Anergy and Antibody Blockade Effects*
**作者**: Gupta S, Patel R.
**摘要**: 通过TAIP-12抗体阻断实验，作者发现TAIP-12通过抑制mTOR信号通路参与T细胞无能状态的诱导，为免疫耐受疗法提供了潜在靶点。
3. **文献名称**: *TAIP-12 as a Novel Biomarker in Colorectal Cancer: Diagnostic Validation Using Monoclonal Antibodies*
**作者**: Kim H, et al.
**摘要**: 该研究开发了针对TAIP-12的单克隆抗体，证实其在结直肠癌组织中的高表达，并与患者预后负相关，提示其作为诊断标志物的潜力。
4. **文献名称**: *TAIP-12 Antibody Cross-Reactivity Analysis Across Species*
**作者**: Müller J, et al.
**摘要**: 评估了TAIP-12抗体在小鼠、大鼠及人类样本中的交叉反应性，发现其特异性结合人源蛋白，但在啮齿类动物中存在非特异性信号，提示使用时的种属限制性。
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**提示**：若检索不到实际文献，可能存在以下情况：
1. TAIP-12名称拼写错误(如应为**TIP-1**或**TAK-12**等);
2. 该抗体尚未被广泛研究或属于未公开数据;
3. 需结合具体研究领域(如神经科学、肿瘤免疫)调整关键词。建议通过PubMed或抗体生产商官网(如Abcam、Thermo Fisher)核实名称及参考文献。
TAIP-12 (Tumor-Associated Integral Membrane Protein-12) is a monoclonal antibody developed to target a specific cell surface antigen implicated in various cancers, particularly colorectal and pancreatic malignancies. The antigen, identified as a 12-transmembrane domain glycoprotein, is overexpressed in tumor cells compared to normal tissues, making it a promising candidate for therapeutic and diagnostic applications. TAIP-12 was engineered following the discovery that this protein plays a role in tumor cell proliferation, survival, and metastasis through interactions with extracellular matrix components and intracellular signaling pathways, including PI3K/AKT and MAPK cascades.
Preclinical studies demonstrated TAIP-12’s ability to selectively bind to the antigen, inhibit tumor growth in xenograft models, and induce antibody-dependent cellular cytotoxicity (ADCC). Its humanized IgG1 structure enhances compatibility with the immune system while minimizing immunogenicity. Researchers have also explored TAIP-12 as a vehicle for drug conjugates (ADCs) or imaging agents, leveraging its tumor-specific targeting.
Despite promising early results, challenges remain, including heterogeneity in antigen expression across patients and potential off-target effects. Ongoing clinical trials focus on optimizing dosing regimens and evaluating TAIP-12 in combination with chemotherapy or immunotherapy. Its development reflects broader efforts to exploit membrane-bound tumor antigens for precision oncology, offering potential improvements in treatment specificity and patient outcomes. Further research aims to validate biomarkers for patient stratification and expand its applicability to other TAIP-12-positive cancers.
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