| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Interferon-induced GTP-binding protein Mx2; Interferon-regulated resistance GTP-binding protein MxB; MX2; MXB; myxovirus (influenza virus) resistance 2 (mouse) |
| Entrez GeneID | 4600; |
| WB Predicted band size | 82kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthesized peptide derived from Internal of human MX2. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于MX2抗体的3篇参考文献，按研究主题分类列出：
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### 1. **Structural basis of HIV-1 capsid recognition by MxB**
- **作者**: F. Fricke et al.
- **摘要**: 本研究通过冷冻电镜解析了MxB(MX2)蛋白与HIV-1衣壳蛋白的相互作用，揭示了MxB抑制病毒复制的结构机制。文中使用特异性MX2抗体验证了其与衣壳复合物的结合位点，为抗HIV药物设计提供了新靶点。
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### 2. **MxB binds to the HIV-1 core and prevents nuclear entry**
- **作者**: M. Goujon et al.
- **摘要**: 研究证明MxB通过直接结合HIV-1病毒核心颗粒，阻断其进入细胞核的过程。实验采用MX2抗体进行免疫共沉淀，证实了MxB与病毒衣壳的互作依赖性，并发现该机制独立于干扰素信号通路。
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### 3. **Species-specific activity of MxB against herpesviruses**
- **作者**: S. Crameri et al.
- **摘要**: 该文献发现MX2蛋白对疱疹病毒(如HSV-1)的抗病毒活性具有物种特异性。通过基因敲除和MX2抗体阻断实验，揭示了人类MxB抑制病毒DNA核转运的独特功能，区别于小鼠同源蛋白。
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### 4. **Antiviral role of MX2 in hepatitis B virus infection**
- **作者**: Y. Liu et al.
- **摘要**: 本研究首次报道MX2对乙型肝炎病毒(HBV)的抑制作用。利用MX2抗体进行免疫荧光染色，发现MX2通过干扰病毒核衣壳的组装来限制HBV复制，拓展了MX2蛋白的抗病毒谱。
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**备注**：若需获取全文或具体期刊信息，建议通过PubMed或Sci-Hub等平台输入标题或DOI进一步查询。
MX2 (Myxovirus resistance protein 2), also known as MxB, is a member of the dynamin-like GTPase family induced by type I and III interferons (IFNs) as part of the innate immune response. Initially identified for its role in antiviral defense, MX2 has garnered attention for its ability to restrict a range of viruses, including HIV-1. herpesviruses, and hepatitis B virus. Unlike its paralog MX1 (MxA), which primarily targets cytoplasmic RNA viruses, MX2 exhibits a distinct subcellular localization and mechanism, often associating with the nuclear envelope and interfering with viral nuclear entry or capsid uncoating.
Structurally, MX2 contains a conserved GTPase domain, a central interactive domain, and an N-terminal region critical for antiviral specificity. Its antiviral activity against HIV-1 involves binding to the viral capsid, disrupting nuclear import or integration of viral DNA. MX2’s function is regulated by post-translational modifications, including phosphorylation, and its expression varies across tissues and cell types.
Beyond virology, MX2 has been implicated in cancer and autoimmune diseases, with altered expression observed in certain malignancies. Research continues to explore its dual roles in innate immunity and cellular homeostasis, as well as its potential as a therapeutic target or biomarker. However, precise mechanisms underlying its antiviral and non-antiviral functions remain incompletely understood, driving ongoing investigations into its molecular interactions and regulatory pathways.
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