| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Keratin; type I cuticular Ha8; Hair keratin; type I Ha8; Keratin-38 |
| Entrez GeneID | 8687; |
| WB Predicted band size | 50kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthesized peptide derived from internal of human KRT37/38. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于KRT37和KRT38抗体的3篇参考文献示例(部分信息为假设性概括，供参考)：
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1. **标题**: *Characterization of KRT37 as a novel biomarker in colorectal cancer progression*
**作者**: Smith A, et al.
**摘要**: 本研究通过KRT37特异性抗体，在结直肠癌组织中发现KRT37蛋白的异常高表达，与肿瘤侵袭性呈正相关。抗体应用于免疫组化，证实其在癌症早期诊断中的潜在价值。
2. **标题**: *KRT38 expression in human hair follicle stem cells: A role in epithelial differentiation*
**作者**: Lee J, et al.
**摘要**: 利用KRT38抗体进行免疫荧光分析，揭示了该蛋白在毛囊干细胞分化为角质形成细胞过程中的动态表达，提示其在上皮组织再生中的调控作用。
3. **标题**: *Dual antibody-based detection of KRT37 and KRT38 in esophageal squamous cell carcinoma*
**作者**: Wang Y, et al.
**摘要**: 开发了同时靶向KRT37和KRT38的双抗体检测方法，证实两者在食管鳞癌中的共表达特征，并与患者预后不良相关，可能作为联合生物标志物。
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**备注**：以上文献为示例，实际研究中请通过PubMed或Web of Science等平台，以“KRT37 antibody”或“Keratin 38 immunohistochemistry”等关键词检索最新文献。部分真实研究可能集中于角蛋白在特定癌症或组织工程中的应用。
Keratins are a family of intermediate filament proteins essential for maintaining the structural integrity of epithelial cells. KRT37 and KRT38 are type I acidic keratins encoded by genes located in the keratin gene cluster on chromosome 17q21.2. These keratins are primarily expressed in specialized epithelial tissues, including hair follicles, nail beds, and certain glandular epithelia. Their expression patterns are often tightly regulated during cellular differentiation and development.
Antibodies targeting KRT37 and KRT38 are valuable tools in biomedical research and diagnostics. They are frequently used in immunohistochemistry (IHC) and immunofluorescence (IF) to study epithelial cell differentiation, tissue-specific keratin expression, and pathological changes in diseases. For example, aberrant expression of KRT37/KRT38 has been observed in various neoplasms, including skin tumors and adenocarcinomas, suggesting their potential role as biomarkers for tumor classification or progression.
These antibodies also aid in understanding hair follicle biology, as KRT37/KRT38 contribute to the structural organization of trichocytes. Commercially available monoclonal and polyclonal antibodies are validated for specificity across human and model organism tissues. However, cross-reactivity with other type I keratins requires careful experimental controls. Ongoing research explores their functional roles beyond structural support, including interactions in signaling pathways and cellular stress responses.
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